MicroRNA-mediated control of Epstein–Barr virus infection and potential diagnostic and therapeutic implications

Research output: Contribution to journalReview articlepeer-review

Abstract

Herpesviruses, such as Epstein–Barr virus (EBV), encode multiple viral microRNAs that are expressed throughout various infection stages. While much progress has been made in evaluating both the viral and host microRNAs (miRNAs) that are detected during infection as well as elucidating their molecular targets in vitro, our understanding of their contributions to pathogenesis in vivo, viral oncogenesis, and clinical implications for these small molecules remains limited. miRNAs are widely recognized as key regulators of global cellular processes, including apoptosis, cell differentiation, and development of immune responses. This review discusses the roles of miRNAs in EBV infection and current advances in miRNA-based diagnostic and therapeutic strategies potentially applicable toward EBV-associated diseases.

Original languageEnglish (US)
Article number101272
JournalCurrent Opinion in Virology
Volume56
DOIs
StatePublished - Oct 2022

ASJC Scopus subject areas

  • Virology

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