Microcirculatory changes in the lung of the hypoxic and hypovolemic puppy: an electron microscope study

M. W. Harrison, R. S. Connell, J. R. Campbell, M. C. Webb

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

The effect of systemic hypoxemia and hypovolemia on pulmonary fine structure was studied and compared in 12 Labrador puppies 6 days to 3 wk old. Central venous and arterial pressures were monitored and arterial pH, PCO2 and PO2 recorded serially. In 4 puppies lung biopsies were taken after a 2 h period of breathing 7% oxygen. Four other puppies were made hypovolemic by acute hemorrhage of 50% of the calculated blood volume and lung biopsies taken after 1 hr. Four control puppies were maintained under anesthesia for 2 hr, breathing an atmosphere of 20% oxygen before lung biopsies were taken. Both hypoxemia and hypovolemia resulted in similar pulmonary ultrastructural changes. These changes which occurred more frequently in areas where the air spaces and blood vessels were expanded, were characterized by aggregation of platelets and leukocytes in the vascular space, focal endothelial cell disruption, interstitial edema and type I epithelial cell discontinuities with exudation of plasma into the alveolar air spaces.

Original languageEnglish (US)
Pages (from-to)311-317
Number of pages7
JournalAnnals of Surgery
Volume185
Issue number3
StatePublished - 1977
Externally publishedYes

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Hypovolemia
Electrons
Lung
Biopsy
Blood Vessels
Respiration
Air
Oxygen
Newfoundland and Labrador
Central Venous Pressure
Blood Volume
Atmosphere
Platelet Aggregation
Edema
Arterial Pressure
Leukocytes
Anesthesia
Endothelial Cells
Epithelial Cells
Hemorrhage

ASJC Scopus subject areas

  • Surgery

Cite this

Harrison, M. W., Connell, R. S., Campbell, J. R., & Webb, M. C. (1977). Microcirculatory changes in the lung of the hypoxic and hypovolemic puppy: an electron microscope study. Annals of Surgery, 185(3), 311-317.

Microcirculatory changes in the lung of the hypoxic and hypovolemic puppy : an electron microscope study. / Harrison, M. W.; Connell, R. S.; Campbell, J. R.; Webb, M. C.

In: Annals of Surgery, Vol. 185, No. 3, 1977, p. 311-317.

Research output: Contribution to journalArticle

Harrison, MW, Connell, RS, Campbell, JR & Webb, MC 1977, 'Microcirculatory changes in the lung of the hypoxic and hypovolemic puppy: an electron microscope study', Annals of Surgery, vol. 185, no. 3, pp. 311-317.
Harrison, M. W. ; Connell, R. S. ; Campbell, J. R. ; Webb, M. C. / Microcirculatory changes in the lung of the hypoxic and hypovolemic puppy : an electron microscope study. In: Annals of Surgery. 1977 ; Vol. 185, No. 3. pp. 311-317.
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