Micro-RNA 155 Is required for Optimal CD8+ T Cell responses to acute viral and intracellular bacterial challenges

Evan Lind, Alisha R. Elford, Pamela S. Ohashi

Research output: Contribution to journalArticle

63 Citations (Scopus)

Abstract

Recent studies have begun to define the role ofmicro-RNAs in regulating the immune response.Micro-RNA155 (mir-155) has been shown to play a role in germinal center formation, T cell inflammation, and regulatory T cell development. In this study, we evaluated the role of mir-155 in cytotoxic T cell function.We report in this study that mice lacking mir-155 have impaired CD8+ T cell responses to infections with lymphocytic choriomeningitis virus and the intracellular bacteria Listeria monocytogenes.We show by a series of adoptive transfer studies that the impaired CD8+ T cell response to L. monocytogenes is T cell intrinsic. In addition, we observed that CD8+ T cells lacking mir-155 have impaired activation of the prosurvival Akt pathway after TCR cross-linking. These data suggest that mir-155 may be a good target for therapies aimed at modulating immune responses.

Original languageEnglish (US)
Pages (from-to)1210-1216
Number of pages7
JournalJournal of Immunology
Volume190
Issue number3
DOIs
StatePublished - Feb 1 2013
Externally publishedYes

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MicroRNAs
T-Lymphocytes
Listeria monocytogenes
Lymphocytic choriomeningitis virus
Germinal Center
Adoptive Transfer
Regulatory T-Lymphocytes
RNA
Inflammation
Bacteria
Infection

ASJC Scopus subject areas

  • Immunology

Cite this

Micro-RNA 155 Is required for Optimal CD8+ T Cell responses to acute viral and intracellular bacterial challenges. / Lind, Evan; Elford, Alisha R.; Ohashi, Pamela S.

In: Journal of Immunology, Vol. 190, No. 3, 01.02.2013, p. 1210-1216.

Research output: Contribution to journalArticle

Lind, Evan ; Elford, Alisha R. ; Ohashi, Pamela S. / Micro-RNA 155 Is required for Optimal CD8+ T Cell responses to acute viral and intracellular bacterial challenges. In: Journal of Immunology. 2013 ; Vol. 190, No. 3. pp. 1210-1216.
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