Micro-RNA 155 Is required for Optimal CD8+ T Cell responses to acute viral and intracellular bacterial challenges

Evan F. Lind, Alisha R. Elford, Pamela S. Ohashi

Research output: Contribution to journalArticle

69 Scopus citations

Abstract

Recent studies have begun to define the role ofmicro-RNAs in regulating the immune response.Micro-RNA155 (mir-155) has been shown to play a role in germinal center formation, T cell inflammation, and regulatory T cell development. In this study, we evaluated the role of mir-155 in cytotoxic T cell function.We report in this study that mice lacking mir-155 have impaired CD8+ T cell responses to infections with lymphocytic choriomeningitis virus and the intracellular bacteria Listeria monocytogenes.We show by a series of adoptive transfer studies that the impaired CD8+ T cell response to L. monocytogenes is T cell intrinsic. In addition, we observed that CD8+ T cells lacking mir-155 have impaired activation of the prosurvival Akt pathway after TCR cross-linking. These data suggest that mir-155 may be a good target for therapies aimed at modulating immune responses.

Original languageEnglish (US)
Pages (from-to)1210-1216
Number of pages7
JournalJournal of Immunology
Volume190
Issue number3
DOIs
StatePublished - Feb 1 2013

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Fingerprint Dive into the research topics of 'Micro-RNA 155 Is required for Optimal CD<sub>8</sub>+ T Cell responses to acute viral and intracellular bacterial challenges'. Together they form a unique fingerprint.

  • Cite this