Mice genetically selected for differences in open-field activity after ethanol

John C. Crabbe; Emmett R. Young; Catherine M. Deutsch; Brenda R. Tam; Ann Kosobud

doi:10.1016/0091-3057(87)90371-6

Mice genetically selected for differences in open-field activity after ethanol

John C. Crabbe, Emmett R. Young, Catherine M. Deutsch, Brenda R. Tam, Ann Kosobud

Behavioral Neuroscience

Research output: Contribution to journal › Article › peer-review

86 Scopus citations

Abstract

Starting from a population of genetically heterogeneous mice, selective breeding is being used to develop lines differing in sensitivity to ethanol-induced open-field activity. Mice are tested twice for 4 min in an open field. The first test is between min 2-6 after injection of saline. Twenty-four hr later, a similar test is performed after injection of ethanol (1.5 g/kg). Two independent FAST lines are being selected for ethanol-induced increases in activity, and two independent SLOW lines are being selected for ethanol-induced decreases. After four generations of selection, the lines have diverged significantly. These lines should be useful for exploring the neuropharmacological basis for the activating and rewarding properties of ethanol.

Original language	English (US)
Pages (from-to)	577-581
Number of pages	5
Journal	Pharmacology, Biochemistry and Behavior
Volume	27
Issue number	3
DOIs	https://doi.org/10.1016/0091-3057(87)90371-6
State	Published - Jul 1987

Keywords

Behavioral genetics
Selective breeding, Pharmacogenetics, Open-field activity, Ethanol stimulation, Reward, Activity

ASJC Scopus subject areas

Biochemistry
Toxicology
Pharmacology
Clinical Biochemistry
Biological Psychiatry
Behavioral Neuroscience

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10.1016/0091-3057(87)90371-6

Cite this

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title = "Mice genetically selected for differences in open-field activity after ethanol",

abstract = "Starting from a population of genetically heterogeneous mice, selective breeding is being used to develop lines differing in sensitivity to ethanol-induced open-field activity. Mice are tested twice for 4 min in an open field. The first test is between min 2-6 after injection of saline. Twenty-four hr later, a similar test is performed after injection of ethanol (1.5 g/kg). Two independent FAST lines are being selected for ethanol-induced increases in activity, and two independent SLOW lines are being selected for ethanol-induced decreases. After four generations of selection, the lines have diverged significantly. These lines should be useful for exploring the neuropharmacological basis for the activating and rewarding properties of ethanol.",

keywords = "Behavioral genetics, Selective breeding, Pharmacogenetics, Open-field activity, Ethanol stimulation, Reward, Activity",

author = "Crabbe, {John C.} and Young, {Emmett R.} and Deutsch, {Catherine M.} and Tam, {Brenda R.} and Ann Kosobud",

note = "Funding Information: These experiments were supported by grants AA06498, AA06423, and AA05828 from PHS-ADAMHA-NIAAA and by a grant from the Veterans Administration",

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AU - Crabbe, John C.

AU - Young, Emmett R.

AU - Deutsch, Catherine M.

AU - Tam, Brenda R.

AU - Kosobud, Ann

N1 - Funding Information: These experiments were supported by grants AA06498, AA06423, and AA05828 from PHS-ADAMHA-NIAAA and by a grant from the Veterans Administration

PY - 1987/7

Y1 - 1987/7

N2 - Starting from a population of genetically heterogeneous mice, selective breeding is being used to develop lines differing in sensitivity to ethanol-induced open-field activity. Mice are tested twice for 4 min in an open field. The first test is between min 2-6 after injection of saline. Twenty-four hr later, a similar test is performed after injection of ethanol (1.5 g/kg). Two independent FAST lines are being selected for ethanol-induced increases in activity, and two independent SLOW lines are being selected for ethanol-induced decreases. After four generations of selection, the lines have diverged significantly. These lines should be useful for exploring the neuropharmacological basis for the activating and rewarding properties of ethanol.

AB - Starting from a population of genetically heterogeneous mice, selective breeding is being used to develop lines differing in sensitivity to ethanol-induced open-field activity. Mice are tested twice for 4 min in an open field. The first test is between min 2-6 after injection of saline. Twenty-four hr later, a similar test is performed after injection of ethanol (1.5 g/kg). Two independent FAST lines are being selected for ethanol-induced increases in activity, and two independent SLOW lines are being selected for ethanol-induced decreases. After four generations of selection, the lines have diverged significantly. These lines should be useful for exploring the neuropharmacological basis for the activating and rewarding properties of ethanol.

KW - Behavioral genetics

KW - Selective breeding, Pharmacogenetics, Open-field activity, Ethanol stimulation, Reward, Activity

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Mice genetically selected for differences in open-field activity after ethanol

Abstract

Keywords

ASJC Scopus subject areas

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