MHC class I immune evasion in MCMV infection

Carmen M. Doom; Ann B. Hill

doi:10.1007/s00430-008-0089-y

MHC class I immune evasion in MCMV infection

Carmen M. Doom, Ann B. Hill

Research output: Contribution to journal › Review article › peer-review

56 Scopus citations

Abstract

Murine cytomegalovirus (MCMV) is a well-studied model of natural β-herpesvirus infection. However, many questions remain regarding its control by and evasion of the immune response it generates. CD8 and CD4 T cells have both unique and redundant roles in control of the virus that differ based on the immunocompetence of the infected mice. MCMV encodes major histocompatibility complex (MHC) class I immune evasion genes that can have an impact in vitro, but their role in infection of immunocompetent mice has been difficult to identify. This review addresses the evidence for their in vivo function and suggests why they may be evolutionarily conserved.

Original language	English (US)
Pages (from-to)	191-204
Number of pages	14
Journal	Medical Microbiology and Immunology
Volume	197
Issue number	2
DOIs	https://doi.org/10.1007/s00430-008-0089-y
State	Published - Jun 2008
Externally published	Yes

Keywords

CD8 T cell control
Immune evasion
MCMV
MHC class I
Natural infection

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Microbiology (medical)

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10.1007/s00430-008-0089-y

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abstract = "Murine cytomegalovirus (MCMV) is a well-studied model of natural β-herpesvirus infection. However, many questions remain regarding its control by and evasion of the immune response it generates. CD8 and CD4 T cells have both unique and redundant roles in control of the virus that differ based on the immunocompetence of the infected mice. MCMV encodes major histocompatibility complex (MHC) class I immune evasion genes that can have an impact in vitro, but their role in infection of immunocompetent mice has been difficult to identify. This review addresses the evidence for their in vivo function and suggests why they may be evolutionarily conserved.",

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AU - Hill, Ann B.

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AB - Murine cytomegalovirus (MCMV) is a well-studied model of natural β-herpesvirus infection. However, many questions remain regarding its control by and evasion of the immune response it generates. CD8 and CD4 T cells have both unique and redundant roles in control of the virus that differ based on the immunocompetence of the infected mice. MCMV encodes major histocompatibility complex (MHC) class I immune evasion genes that can have an impact in vitro, but their role in infection of immunocompetent mice has been difficult to identify. This review addresses the evidence for their in vivo function and suggests why they may be evolutionarily conserved.

KW - CD8 T cell control

KW - Immune evasion

KW - MCMV

KW - MHC class I

KW - Natural infection

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MHC class I immune evasion in MCMV infection

Abstract

Keywords

ASJC Scopus subject areas

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