MHC class I immune evasion in MCMV infection

Carmen M. Doom, Ann B. Hill

Research output: Contribution to journalReview article

51 Scopus citations

Abstract

Murine cytomegalovirus (MCMV) is a well-studied model of natural β-herpesvirus infection. However, many questions remain regarding its control by and evasion of the immune response it generates. CD8 and CD4 T cells have both unique and redundant roles in control of the virus that differ based on the immunocompetence of the infected mice. MCMV encodes major histocompatibility complex (MHC) class I immune evasion genes that can have an impact in vitro, but their role in infection of immunocompetent mice has been difficult to identify. This review addresses the evidence for their in vivo function and suggests why they may be evolutionarily conserved.

Original languageEnglish (US)
Pages (from-to)191-204
Number of pages14
JournalMedical Microbiology and Immunology
Volume197
Issue number2
DOIs
StatePublished - Jun 1 2008

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Keywords

  • CD8 T cell control
  • Immune evasion
  • MCMV
  • MHC class I
  • Natural infection

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Microbiology (medical)

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