Methionine recycling as a target for antiprotozoal drug development

M. K. Riscoe, A. J. Ferro, J. H. Fitchen

Research output: Contribution to journalArticle

35 Scopus citations

Abstract

The development of new and effective ontiprotozool drugs has been difficult because of the close metabolic relationship between protozoa and mammalian cells. In this article, Michael Riscoe, Al Ferro and john Fitchen present their hypothesis for chemotherapeutic exploitation of methylthioribose (MTR) kinase, an enzyme critical to methionine salvage in certain protozoa. They propose that analogues of MTR if properly designed, would be converted to toxic products in organisms that contain MTR kinase but not in mammalian cells, which lack this enzyme.

Original languageEnglish (US)
Pages (from-to)330-333
Number of pages4
JournalParasitology Today
Volume5
Issue number10
DOIs
StatePublished - Oct 1989

ASJC Scopus subject areas

  • Parasitology

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