Meta-analysis of randomized controlled trials on primary ambulatory thromboprophylaxis in patients with nonpancreatic gastrointestinal cancers receiving chemotherapy

Thura Win Htut, Kyaw Zin Thein, Donald Paul Quick, Thein Hlaing Oo

Research output: Contribution to journalArticlepeer-review

Abstract

Primary ambulatory thromboprophylaxis (PATP) in patients with solid malignancies is not routinely indicated. We performed a meta-analysis of randomized controlled trials (RCTs) to determine the benefit and risk of PATP in patients with nonpancreatic gastrointestinal cancers receiving chemotherapy. RCTs with venous thromboembolism (VTE) reduction as primary or secondary endpoints were included. A total of 1932 patients from subgroups of 3 RCTs were eligible. The VTE incidence was 1.26% and 2.55% in PATP and control arms, respectively (risk ratio 0.49; confidence interval 0.25 to 0.96; P = 0.04), with a number needed to treat of 78 to prevent one VTE event. In gastric and gastroesophageal junction cancer patients, the VTE incidence was 1.37% and 3.40% in PATP and control arms, respectively (risk ratio 0.40; confidence interval 0.13 to 1.24; P = 0.11). PATP should not be recommended in patients with nonpancreatic gastrointestinal cancers on chemotherapy.

Original languageEnglish (US)
JournalBaylor University Medical Center Proceedings
DOIs
StateAccepted/In press - 2021

Keywords

  • Ambulatory thromboprophylaxis
  • colorectal cancer
  • gastric cancer
  • gastroesophageal junctional cancer
  • meta-analysis
  • venous thromboembolism

ASJC Scopus subject areas

  • Medicine(all)

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