Merlin

Hanging tumor suppression on the Rac

Lawrence (Larry) Sherman, David H. Gutmann

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

Cancer can result from any number of abnormalities in the control of cell-cycle progression, intracellular signaling and transduction of extracellular cues. Many insights into the crucial events that govern the regulation of cell growth have derived from studies of the gene products mutated in inherited cancer syndromes. Recent work on the neurofibromatosis 2 (NF2) tumor suppressor gene suggests that this negative growth regulator might function by modulating growth factor and extracellular matrix (ECM) signals that trigger Rac1-dependent cytoskeleton-associated processes. In this article, we propose a molecular model for NF2 protein (merlin) function in the light of these and related new findings.

Original languageEnglish (US)
Pages (from-to)442-444
Number of pages3
JournalTrends in Cell Biology
Volume11
Issue number11
DOIs
StatePublished - Nov 1 2001
Externally publishedYes

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Neurofibromin 2
Neurofibromatosis 2
Molecular Models
Growth
Cell Cycle Checkpoints
Tumor Suppressor Genes
Cytoskeleton
Cues
Extracellular Matrix
Neoplasms
Intercellular Signaling Peptides and Proteins
Genes
Proteins

ASJC Scopus subject areas

  • Cell Biology

Cite this

Merlin : Hanging tumor suppression on the Rac. / Sherman, Lawrence (Larry); Gutmann, David H.

In: Trends in Cell Biology, Vol. 11, No. 11, 01.11.2001, p. 442-444.

Research output: Contribution to journalArticle

Sherman, Lawrence (Larry) ; Gutmann, David H. / Merlin : Hanging tumor suppression on the Rac. In: Trends in Cell Biology. 2001 ; Vol. 11, No. 11. pp. 442-444.
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