Membrane phospholipid control of nucleotide sensitivity of K(ATP) channels

S. L. Shyng, C. G. Nichols

Research output: Contribution to journalArticle

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Abstract

Adenosine triphosphate (ATP)-sensitive potassium (K(ATP)) channels couple cell metabolism to electrical activity. Phosphatidylinositol phosphates (PIPs) profoundly antagonized ATP inhibition of K(ATP) channels when applied to inside-out membrane patches. It is proposed that membrane- incorporated PIPs can bind to positive charges in the cytoplasmic region of the channel's K(ir)6.2 subunit, stabilizing the open state of the channel and antagonizing the inhibitory effect of ATP. The tremendous effect of PIPs on ATP sensitivity suggests that in vivo alterations of membrane PIP levels will have substantial effects on K(ATP) channel activity and hence on the gain of metabolism-excitation coupling.

Original languageEnglish (US)
Pages (from-to)1138-1141
Number of pages4
JournalScience
Volume282
Issue number5391
DOIs
StatePublished - Nov 6 1998

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