TY - JOUR
T1 - Melatonin shifts human orcadian rhythms according to a phase-response curve
AU - Lewy, Alfred J.
AU - Ahmed, Saeeduddin
AU - Jackson, Jeanne M.Latham
AU - Sack, Robert L.
N1 - Funding Information:
Acknowledgment: We wish to thank the nursing staff of the OHSU CRC and to acknowledge the assistance of Gregory Clarke, Mary Cardoza, Vance Bauer, Carol A. Gawryla, Neil L. Cutler, and Mary L. Blood. Supported by research grants MH 40161 (AJL), MH 00703 (AJL), and 5M01 RR 00334 (OHSU CRC).
PY - 1992
Y1 - 1992
N2 - A physiological dose of orally administered melatonin shifts circadian rhythms in humans according to a phase-response curve (PRC) that is nearly opposite in phase with the PRCs for light exposure: melatonin delays circadian rhythms when administered in the morning and advances them when administered in the afternoon or early evening. The human melatonin PRC provides critical information for using melatonin to treat circadian phase sleep and mood disorders, as well as maladaptation to shift work and transmeridional air travel. The human melatonin PRC also provides the strongest evidence to date for a function of endogenous melatonin and its suppression by light in augmenting entrainment of circadian rhythms by the light-dark cycle.
AB - A physiological dose of orally administered melatonin shifts circadian rhythms in humans according to a phase-response curve (PRC) that is nearly opposite in phase with the PRCs for light exposure: melatonin delays circadian rhythms when administered in the morning and advances them when administered in the afternoon or early evening. The human melatonin PRC provides critical information for using melatonin to treat circadian phase sleep and mood disorders, as well as maladaptation to shift work and transmeridional air travel. The human melatonin PRC also provides the strongest evidence to date for a function of endogenous melatonin and its suppression by light in augmenting entrainment of circadian rhythms by the light-dark cycle.
KW - Circadian phase shifts
KW - Circadian phase sleep and mood disorders
KW - Dim light melatonin onset (DLMO)
KW - Melatonin administration
KW - Phase-response curve (PRC)
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U2 - 10.3109/07420529209064550
DO - 10.3109/07420529209064550
M3 - Article
C2 - 1394610
AN - SCOPUS:0026661007
SN - 0742-0528
VL - 9
SP - 380
EP - 392
JO - Chronobiology International
JF - Chronobiology International
IS - 5
ER -