Melatonin shifts human orcadian rhythms according to a phase-response curve

Alfred Lewy, Saeeduddin Ahmed, Jeanne M Latham Jackson, Robert Sack

Research output: Contribution to journalArticle

586 Citations (Scopus)

Abstract

A physiological dose of orally administered melatonin shifts circadian rhythms in humans according to a phase-response curve (PRC) that is nearly opposite in phase with the PRCs for light exposure: melatonin delays circadian rhythms when administered in the morning and advances them when administered in the afternoon or early evening. The human melatonin PRC provides critical information for using melatonin to treat circadian phase sleep and mood disorders, as well as maladaptation to shift work and transmeridional air travel. The human melatonin PRC also provides the strongest evidence to date for a function of endogenous melatonin and its suppression by light in augmenting entrainment of circadian rhythms by the light-dark cycle.

Original languageEnglish (US)
Pages (from-to)380-392
Number of pages13
JournalChronobiology International
Volume9
Issue number5
DOIs
StatePublished - 1992

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melatonin
Melatonin
Circadian Rhythm
circadian rhythm
Air Travel
air transportation
Light
work schedules
administered dose
Photoperiod
emotions
sleep
Mood Disorders
photoperiod

Keywords

  • Circadian phase shifts
  • Circadian phase sleep and mood disorders
  • Dim light melatonin onset (DLMO)
  • Melatonin administration
  • Phase-response curve (PRC)

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)
  • Agricultural and Biological Sciences (miscellaneous)

Cite this

Melatonin shifts human orcadian rhythms according to a phase-response curve. / Lewy, Alfred; Ahmed, Saeeduddin; Jackson, Jeanne M Latham; Sack, Robert.

In: Chronobiology International, Vol. 9, No. 5, 1992, p. 380-392.

Research output: Contribution to journalArticle

Lewy, Alfred ; Ahmed, Saeeduddin ; Jackson, Jeanne M Latham ; Sack, Robert. / Melatonin shifts human orcadian rhythms according to a phase-response curve. In: Chronobiology International. 1992 ; Vol. 9, No. 5. pp. 380-392.
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