Melanocytes as instigators and victims of oxidative stress

Laurence Denat, Ana L. Kadekaro, Laurent Marrot, Sancy A. Leachman, Zalfa A. Abdel-Malek

Research output: Contribution to journalReview article

123 Scopus citations

Abstract

Epidermal melanocytes are particularly vulnerable to oxidative stress owing to the pro-oxidant state generated during melanin synthesis, and to the intrinsic antioxidant defenses that are compromised in pathologic conditions. Melanoma is thought to be oxidative stress driven, and melanocyte death in vitiligo is thought to be instigated by a highly pro-oxidant state in the epidermis. We review the current knowledge about melanin and the redox state of melanocytes, how paracrine factors help counteract oxidative stress, the role of oxidative stress in melanoma initiation and progression and in melanocyte death in vitiligo, and how this knowledge can be harnessed for melanoma and vitiligo treatment.

Original languageEnglish (US)
Pages (from-to)1512-1518
Number of pages7
JournalJournal of Investigative Dermatology
Volume134
Issue number6
DOIs
StatePublished - Jan 1 2014

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Dermatology
  • Cell Biology

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