Melanocytes as instigators and victims of oxidative stress

Laurence Denat, Ana L. Kadekaro, Laurent Marrot, Sancy Leachman, Zalfa A. Abdel-Malek

Research output: Contribution to journalArticle

99 Citations (Scopus)

Abstract

Epidermal melanocytes are particularly vulnerable to oxidative stress owing to the pro-oxidant state generated during melanin synthesis, and to the intrinsic antioxidant defenses that are compromised in pathologic conditions. Melanoma is thought to be oxidative stress driven, and melanocyte death in vitiligo is thought to be instigated by a highly pro-oxidant state in the epidermis. We review the current knowledge about melanin and the redox state of melanocytes, how paracrine factors help counteract oxidative stress, the role of oxidative stress in melanoma initiation and progression and in melanocyte death in vitiligo, and how this knowledge can be harnessed for melanoma and vitiligo treatment.

Original languageEnglish (US)
Pages (from-to)1512-1518
Number of pages7
JournalJournal of Investigative Dermatology
Volume134
Issue number6
DOIs
StatePublished - 2014

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Oxidative stress
Melanocytes
Vitiligo
Oxidative Stress
Melanoma
Melanins
Reactive Oxygen Species
Epidermis
Oxidation-Reduction
Antioxidants

ASJC Scopus subject areas

  • Dermatology
  • Biochemistry
  • Cell Biology
  • Molecular Biology

Cite this

Melanocytes as instigators and victims of oxidative stress. / Denat, Laurence; Kadekaro, Ana L.; Marrot, Laurent; Leachman, Sancy; Abdel-Malek, Zalfa A.

In: Journal of Investigative Dermatology, Vol. 134, No. 6, 2014, p. 1512-1518.

Research output: Contribution to journalArticle

Denat, L, Kadekaro, AL, Marrot, L, Leachman, S & Abdel-Malek, ZA 2014, 'Melanocytes as instigators and victims of oxidative stress', Journal of Investigative Dermatology, vol. 134, no. 6, pp. 1512-1518. https://doi.org/10.1038/jid.2014.65
Denat, Laurence ; Kadekaro, Ana L. ; Marrot, Laurent ; Leachman, Sancy ; Abdel-Malek, Zalfa A. / Melanocytes as instigators and victims of oxidative stress. In: Journal of Investigative Dermatology. 2014 ; Vol. 134, No. 6. pp. 1512-1518.
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