Mechanisms of membrane deformation

Khashayar Farsad, Pietro De Camilli

Research output: Contribution to journalReview article

223 Scopus citations

Abstract

Membrane traffic requires the generation of high-curvature lipid-bound transport carriers represented by tubules and vesicles. The mechanisms through which membranes are deformed has gained much recent attention. A major advance has been the demonstration that direct interactions between cytosolic proteins and lipid bilayers are important in the acquisition of membrane curvature. Rather than being driven only by the formation of membrane-associated structural scaffolds, membrane deformation requires physical perturbation of the lipid bilayer. A variety of proteins have been identified that directly bind and deform membranes. An emerging theme in this process is the importance of amphipathic peptides that partially penetrate the lipid bilayer.

Original languageEnglish (US)
Pages (from-to)372-381
Number of pages10
JournalCurrent Opinion in Cell Biology
Volume15
Issue number4
DOIs
StatePublished - Aug 2003

ASJC Scopus subject areas

  • Cell Biology

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