Mechanism of the Sex Difference in Endothelial Dysfunction after Stroke

Catherine Davis, Stacy L. Fairbanks, Nabil Alkayed

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Stroke, the number four cause of death in the USA, is a greatly debilitating event resulting from insufficient blood supply to the brain (cerebral ischemia). Endothelial dysfunction, primarily characterized by dampened endothelial-dependent vasodilation, is a major contributor to the development and outcome of stroke. This review discusses the role of soluble epoxide hydrolase, an enzyme responsible for the degradation of vasoprotective epoxyeicosatrienoic acids, in the context of the cerebral vasculature and its contribution to the sexual dimorphic nature of stroke.

Original languageEnglish (US)
Pages (from-to)381-389
Number of pages9
JournalTranslational Stroke Research
Volume4
Issue number4
DOIs
StatePublished - Aug 2013

Fingerprint

Sex Characteristics
Stroke
Brain Ischemia
Epoxide Hydrolases
Vasodilation
Cause of Death
Acids
Enzymes

Keywords

  • Brain
  • EET
  • Endothelia
  • Ischemia
  • sEH
  • Sexual dimorphism

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)
  • Cardiology and Cardiovascular Medicine

Cite this

Mechanism of the Sex Difference in Endothelial Dysfunction after Stroke. / Davis, Catherine; Fairbanks, Stacy L.; Alkayed, Nabil.

In: Translational Stroke Research, Vol. 4, No. 4, 08.2013, p. 381-389.

Research output: Contribution to journalArticle

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