TY - JOUR
T1 - Mechanism of epithelial lithium transport
T2 - Evidence for basolateral Na: Na and Na: L1 exchange
AU - Kirk, Kevin L.
AU - Dawson, David C.
PY - 1983/10/1
Y1 - 1983/10/1
N2 - Measurement of transmural sodium fluxes across isolated, ouabain-inhibited turtle colon in the presence of a serosal-to-mucosal sodium gradient shows that in the absence of active transport the amiloride-sensitive cellular path contains at least two routes for the transmural movement of sodium and lithium, one a conductive path and the other a nonconductive, cation-exchange mechanism. The latter transport element can exchange lithium for sodium, and the countertransport of these two cations provides a mechanistic basis for the ability of tight epithelia to actively absorb lithium despite the low affinity of the basolateral Na/K-ATPase for this cation.
AB - Measurement of transmural sodium fluxes across isolated, ouabain-inhibited turtle colon in the presence of a serosal-to-mucosal sodium gradient shows that in the absence of active transport the amiloride-sensitive cellular path contains at least two routes for the transmural movement of sodium and lithium, one a conductive path and the other a nonconductive, cation-exchange mechanism. The latter transport element can exchange lithium for sodium, and the countertransport of these two cations provides a mechanistic basis for the ability of tight epithelia to actively absorb lithium despite the low affinity of the basolateral Na/K-ATPase for this cation.
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U2 - 10.1085/jgp.82.4.497
DO - 10.1085/jgp.82.4.497
M3 - Article
C2 - 6644269
AN - SCOPUS:0020634699
SN - 0022-1295
VL - 82
SP - 497
EP - 510
JO - Journal of General Physiology
JF - Journal of General Physiology
IS - 4
ER -