Measurements of human brain ethanol T2 by spectroscopic imaging at 4 T

Manoj Sammi, Jullie W. Pan, Frank W. Telang, Donna Schuhlein, Patricia E. Molina, Nora D. Volkow, Charles Jr Springer, Hoby P. Hetherington

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Previous MRS measurements of ethanol in human brain have yielded a range of transverse relaxation times for ethanol methyl resonance at 1.5 T (200-380 ms). To determine the T2 of the methyl proton resonance of ethanol in human brain, 8 x 8 spectroscopic images were acquired at 16 different TE values. A frequency-selective refocusing pulse was used to suppress J-modulation of the ethanol triplet, permitting nonintegral multiples of 1/J to be used for TE values. The measured T2 values for the methyl resonances of ethanol, creatine, and N-acetyl aspartate in mixed tissues were 82 ± 12, 148 ± 20, and 227 ± 25 ms, respectively. Regression analysis of the measured T2 as a function of gray matter content indicates a shorter T2 value for ethanol in pure white matter compared to that in pure gray matter. (C) 2000 Wiley-Liss, Inc.

Original languageEnglish (US)
Pages (from-to)35-40
Number of pages6
JournalMagnetic Resonance in Medicine
Volume44
Issue number1
DOIs
StatePublished - 2000
Externally publishedYes

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Ethanol
Brain
Creatine
Protons
Regression Analysis
Gray Matter

Keywords

  • Brain
  • Ethanol
  • Spectroscopy
  • T

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

Sammi, M., Pan, J. W., Telang, F. W., Schuhlein, D., Molina, P. E., Volkow, N. D., ... Hetherington, H. P. (2000). Measurements of human brain ethanol T2 by spectroscopic imaging at 4 T. Magnetic Resonance in Medicine, 44(1), 35-40. https://doi.org/10.1002/1522-2594(200007)44:1<35::AID-MRM7>3.0.CO;2-G

Measurements of human brain ethanol T2 by spectroscopic imaging at 4 T. / Sammi, Manoj; Pan, Jullie W.; Telang, Frank W.; Schuhlein, Donna; Molina, Patricia E.; Volkow, Nora D.; Springer, Charles Jr; Hetherington, Hoby P.

In: Magnetic Resonance in Medicine, Vol. 44, No. 1, 2000, p. 35-40.

Research output: Contribution to journalArticle

Sammi, Manoj ; Pan, Jullie W. ; Telang, Frank W. ; Schuhlein, Donna ; Molina, Patricia E. ; Volkow, Nora D. ; Springer, Charles Jr ; Hetherington, Hoby P. / Measurements of human brain ethanol T2 by spectroscopic imaging at 4 T. In: Magnetic Resonance in Medicine. 2000 ; Vol. 44, No. 1. pp. 35-40.
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