Previous MRS measurements of ethanol in human brain have yielded a range of transverse relaxation times for ethanol methyl resonance at 1.5 T (200-380 ms). To determine the T2 of the methyl proton resonance of ethanol in human brain, 8 x 8 spectroscopic images were acquired at 16 different TE values. A frequency-selective refocusing pulse was used to suppress J-modulation of the ethanol triplet, permitting nonintegral multiples of 1/J to be used for TE values. The measured T2 values for the methyl resonances of ethanol, creatine, and N-acetyl aspartate in mixed tissues were 82 ± 12, 148 ± 20, and 227 ± 25 ms, respectively. Regression analysis of the measured T2 as a function of gray matter content indicates a shorter T2 value for ethanol in pure white matter compared to that in pure gray matter. (C) 2000 Wiley-Liss, Inc.
|Original language||English (US)|
|Number of pages||6|
|Journal||Magnetic Resonance in Medicine|
|State||Published - 2000|
ASJC Scopus subject areas
- Radiology Nuclear Medicine and imaging