Measurements of human brain ethanol T2 by spectroscopic imaging at 4 T

Manoj K. Sammi, Jullie W. Pan, Frank W. Telang, Donna Schuhlein, Patricia E. Molina, Nora D. Volkow, Charles S. Springer, Hoby P. Hetherington

Research output: Contribution to journalArticlepeer-review

16 Scopus citations

Abstract

Previous MRS measurements of ethanol in human brain have yielded a range of transverse relaxation times for ethanol methyl resonance at 1.5 T (200-380 ms). To determine the T2 of the methyl proton resonance of ethanol in human brain, 8 x 8 spectroscopic images were acquired at 16 different TE values. A frequency-selective refocusing pulse was used to suppress J-modulation of the ethanol triplet, permitting nonintegral multiples of 1/J to be used for TE values. The measured T2 values for the methyl resonances of ethanol, creatine, and N-acetyl aspartate in mixed tissues were 82 ± 12, 148 ± 20, and 227 ± 25 ms, respectively. Regression analysis of the measured T2 as a function of gray matter content indicates a shorter T2 value for ethanol in pure white matter compared to that in pure gray matter. (C) 2000 Wiley-Liss, Inc.

Original languageEnglish (US)
Pages (from-to)35-40
Number of pages6
JournalMagnetic Resonance in Medicine
Volume44
Issue number1
DOIs
StatePublished - 2000
Externally publishedYes

Keywords

  • Brain
  • Ethanol
  • Spectroscopy
  • T

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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