Measurement of gallbladder volume and dynamics by combined spect and planar scintigraphy

Paul Brown, G. T. Krishnamurthy, H. S. Brar, Lori H. Gray, Susan Gilbert

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

A new method is described for measurement of gallbladder volume based on three-dimensional single photon emission computed tomography (SPECT). The technique was first validated in a body phantom that used a balloon to represent the gallbladder. The balloon was inflated with a known volume and SPECT volume was calculated by summing the voxels in each transaxial slice above a percentage count threshold. The SPECT and true volume showed a high linear correlation between 15 to 90 ml (r = 0.99). The mean fasting gallbladder volume using a technetium-99m-labelled hepatobiliary agent in nine normal subjects was 26±2 ml (range 18 to 39 ml). By combining the SPECT measurement with a planar technique, it was also possible to evaluate gallbladder emptying parameters. Following a 3 min infusion of 10 ng kg-1of cholecystokinin octapeptide (CCK), the mean gallbladder ejection rate was 1.2±0.2 ml min-1and the residual volume was 12±2 ml. SPECT offers a new noninvasive method for accurate measurement of gallbladder volume.

Original languageEnglish (US)
Pages (from-to)437-446
Number of pages10
JournalNuclear Medicine Communications
Volume7
Issue number6
StatePublished - 1986

Fingerprint

Gallbladder
Single-Photon Emission-Computed Tomography
Radionuclide Imaging
Gallbladder Emptying
Sincalide
Residual Volume
Technetium
Fasting

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

Brown, P., Krishnamurthy, G. T., Brar, H. S., Gray, L. H., & Gilbert, S. (1986). Measurement of gallbladder volume and dynamics by combined spect and planar scintigraphy. Nuclear Medicine Communications, 7(6), 437-446.

Measurement of gallbladder volume and dynamics by combined spect and planar scintigraphy. / Brown, Paul; Krishnamurthy, G. T.; Brar, H. S.; Gray, Lori H.; Gilbert, Susan.

In: Nuclear Medicine Communications, Vol. 7, No. 6, 1986, p. 437-446.

Research output: Contribution to journalArticle

Brown, P, Krishnamurthy, GT, Brar, HS, Gray, LH & Gilbert, S 1986, 'Measurement of gallbladder volume and dynamics by combined spect and planar scintigraphy', Nuclear Medicine Communications, vol. 7, no. 6, pp. 437-446.
Brown, Paul ; Krishnamurthy, G. T. ; Brar, H. S. ; Gray, Lori H. ; Gilbert, Susan. / Measurement of gallbladder volume and dynamics by combined spect and planar scintigraphy. In: Nuclear Medicine Communications. 1986 ; Vol. 7, No. 6. pp. 437-446.
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