Measurement of gallbladder volume and dynamics by combined spect and planar scintigraphy

Paul H. Brown, G. T. Krishnamurthy, H. S. Brar, Lori H. Gray, Susan Gilbert

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

A new method is described for measurement of gallbladder volume based on three-dimensional single photon emission computed tomography (SPECT). The technique was first validated in a body phantom that used a balloon to represent the gallbladder. The balloon was inflated with a known volume and SPECT volume was calculated by summing the voxels in each transaxial slice above a percentage count threshold. The SPECT and true volume showed a high linear correlation between 15 to 90 ml (r = 0.99). The mean fasting gallbladder volume using a technetium-99m-labelled hepatobiliary agent in nine normal subjects was 26±2 ml (range 18 to 39 ml). By combining the SPECT measurement with a planar technique, it was also possible to evaluate gallbladder emptying parameters. Following a 3 min infusion of 10 ng kg-1of cholecystokinin octapeptide (CCK), the mean gallbladder ejection rate was 1.2±0.2 ml min-1and the residual volume was 12±2 ml. SPECT offers a new noninvasive method for accurate measurement of gallbladder volume.

Original languageEnglish (US)
Pages (from-to)437-446
Number of pages10
JournalNuclear Medicine Communications
Volume7
Issue number6
DOIs
StatePublished - Jun 1986

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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