Measles virus infection results in suppression of both innate and adaptive immune responses to secondary bacterial infection

Mark Slifka, Dirk Homann, Antoinette Tishon, Robb Pagarigan, Michael B.A. Oldstone

    Research output: Contribution to journalArticle

    46 Citations (Scopus)

    Abstract

    Among infectious agents, measles virus (MV) remains a scourge responsible for 1 million deaths per year and is a leading cause of childhood deaths in developing countries. Although MV infection itself is not commonly lethal, MV-induced suppression of the immune system results in a greatly increased susceptibility to opportunistic bacterial infections that are largely responsible for the morbidity and mortality associated with this disease. Despite its clinical importance, the underlying mechanisms of MV-induced immunosuppression remain unresolved. To begin to understand the basis of increased susceptibility to bacterial infections during MV infection, we inoculated transgenic mice expressing the MV receptor, CD46, with MV and Listeria monocytogenes. We found that MV-infected mice were more susceptible to infection with Listeria and that this corresponded with significantly decreased numbers of macrophages and neutrophils in the spleen and substantial defects in IFN-γ production by CD4+ T cells. The reduction in CD11b + macrophages and IFN-γ-producing T cells was due to reduced proliferative expansion and not to enhanced apoptosis or to altered distribution of these cells between spleen, blood, and the lymphatic system. These results document that MV infection can suppress both innate and adaptive immune responses and lead to increased susceptibility to bacterial infection.

    Original languageEnglish (US)
    Pages (from-to)805-810
    Number of pages6
    JournalJournal of Clinical Investigation
    Volume111
    Issue number6
    DOIs
    StatePublished - Jan 1 2003

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    Measles virus
    Adaptive Immunity
    Virus Diseases
    Coinfection
    Bacterial Infections
    Innate Immunity
    Spleen
    Macrophages
    Virus Receptors
    T-Lymphocytes
    Listeriosis
    Lymphatic System
    Opportunistic Infections
    Listeria monocytogenes
    Immunosuppression
    Transgenic Mice
    Developing Countries
    Cause of Death
    Immune System
    Neutrophils

    ASJC Scopus subject areas

    • Medicine(all)

    Cite this

    Measles virus infection results in suppression of both innate and adaptive immune responses to secondary bacterial infection. / Slifka, Mark; Homann, Dirk; Tishon, Antoinette; Pagarigan, Robb; Oldstone, Michael B.A.

    In: Journal of Clinical Investigation, Vol. 111, No. 6, 01.01.2003, p. 805-810.

    Research output: Contribution to journalArticle

    Slifka, Mark ; Homann, Dirk ; Tishon, Antoinette ; Pagarigan, Robb ; Oldstone, Michael B.A. / Measles virus infection results in suppression of both innate and adaptive immune responses to secondary bacterial infection. In: Journal of Clinical Investigation. 2003 ; Vol. 111, No. 6. pp. 805-810.
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