Maturation of the infant rhesus macaque gut microbiome and its role in the development of diarrheal disease

Nicholas Rhoades, Tasha Barr, Sara Hendrickson, Kamm Prongay, Andrew Haertel, Leanne Gill, Laura Garzel, Katrine Whiteson, Mark Slifka, Ilhem Messaoudi

    Research output: Contribution to journalArticle

    1 Citation (Scopus)

    Abstract

    Background: Diarrhea is the second leading cause of death in children under 5 years of age. Enhanced understanding of causal pathways, pathogenesis, and sequelae of diarrhea is urgently needed. Although the gut microbiota is believed to play a role in susceptibility to diarrheal diseases, our understanding of this association remains incomplete. Infant rhesus macaques (Macaca mulatta) are susceptible to diarrhea making them an ideal model to address this question. Results: The maturation of the infant rhesus macaque gut microbiome throughout the first 8 months of life occurs in a similar pattern as that described for human infants. Moreover, the microbiome of the captive reared infant rhesus macaque more closely resembles that of human infants in the developing world than in the western world. Importantly, prior to disease onset, the gut microbiome of infants that later develop diarrhea is enriched in pathways of immunomodulatory metabolite synthesis, while those of infants that remain asymptomatic are enriched in pathways for short-chain fatty acid production. We identify Prevotella strains that are more abundant at 1 month in infants that later develop diarrhea. At 8 months, the microbiomes of animals that experience diarrhea show increased abundance of Campylobacter and a reduction in Helicobacter macacae. Conclusion: The composition of the microbial community could provide a phenotypic marker of an infant's susceptibility to diarrheal disease. Given the significant physiological and immunological similarities between human and nonhuman primates, these findings provide potential markers of susceptibility to diarrhea that could be modulated to improve infant health, especially in the developing world.

    Original languageEnglish (US)
    Article number173
    JournalGenome biology
    Volume20
    Issue number1
    DOIs
    StatePublished - Aug 26 2019

    Fingerprint

    diarrheal disease
    Macaca mulatta
    maturation
    diarrhea
    digestive system
    Diarrhea
    Microbiota
    Prevotella
    Helicobacter
    complications (disease)
    short chain fatty acids
    developing world
    Campylobacter
    microbiome
    infant
    Gastrointestinal Microbiome
    intestinal microorganisms
    Western World
    Western world
    Volatile Fatty Acids

    ASJC Scopus subject areas

    • Ecology, Evolution, Behavior and Systematics
    • Genetics
    • Cell Biology

    Cite this

    Maturation of the infant rhesus macaque gut microbiome and its role in the development of diarrheal disease. / Rhoades, Nicholas; Barr, Tasha; Hendrickson, Sara; Prongay, Kamm; Haertel, Andrew; Gill, Leanne; Garzel, Laura; Whiteson, Katrine; Slifka, Mark; Messaoudi, Ilhem.

    In: Genome biology, Vol. 20, No. 1, 173, 26.08.2019.

    Research output: Contribution to journalArticle

    Rhoades, N, Barr, T, Hendrickson, S, Prongay, K, Haertel, A, Gill, L, Garzel, L, Whiteson, K, Slifka, M & Messaoudi, I 2019, 'Maturation of the infant rhesus macaque gut microbiome and its role in the development of diarrheal disease', Genome biology, vol. 20, no. 1, 173. https://doi.org/10.1186/s13059-019-1789-x
    Rhoades, Nicholas ; Barr, Tasha ; Hendrickson, Sara ; Prongay, Kamm ; Haertel, Andrew ; Gill, Leanne ; Garzel, Laura ; Whiteson, Katrine ; Slifka, Mark ; Messaoudi, Ilhem. / Maturation of the infant rhesus macaque gut microbiome and its role in the development of diarrheal disease. In: Genome biology. 2019 ; Vol. 20, No. 1.
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