Maternal IL-6 during pregnancy can be estimated from newborn brain connectivity and predicts future working memory in offspring

Marc D. Rudolph, Alice M. Graham, Eric Feczko, Oscar Miranda Dominguez, Jerod M. Rasmussen, Rahel Nardos, Sonja Entringer, Pathik D. Wadhwa, Claudia Buss, Damien Fair

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

Several lines of evidence support the link between maternal inflammation during pregnancy and increased likelihood of neurodevelopmental and psychiatric disorders in offspring. This longitudinal study seeks to advance understanding regarding implications of systemic maternal inflammation during pregnancy, indexed by plasma interleukin-6 (IL-6) concentrations, for large-scale brain system development and emerging executive function skills in offspring. We assessed maternal IL-6 during pregnancy, functional magnetic resonance imaging acquired in neonates, and working memory (an important component of executive function) at 2 years of age. Functional connectivity within and between multiple neonatal brain networks can be modeled to estimate maternal IL-6 concentrations during pregnancy. Brain regions heavily weighted in these models overlap substantially with those supporting working memory in a large meta-analysis. Maternal IL-6 also directly accounts for a portion of the variance of working memory at 2 years of age. Findings highlight the association of maternal inflammation during pregnancy with the developing functional architecture of the brain and emerging executive function.

Original languageEnglish (US)
Pages (from-to)1-8
Number of pages8
JournalNature Neuroscience
DOIs
StateAccepted/In press - Apr 9 2018

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Short-Term Memory
Interleukin-6
Mothers
Pregnancy
Executive Function
Brain
Inflammation
Psychiatry
Longitudinal Studies
Meta-Analysis
Magnetic Resonance Imaging

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Maternal IL-6 during pregnancy can be estimated from newborn brain connectivity and predicts future working memory in offspring. / Rudolph, Marc D.; Graham, Alice M.; Feczko, Eric; Miranda Dominguez, Oscar; Rasmussen, Jerod M.; Nardos, Rahel; Entringer, Sonja; Wadhwa, Pathik D.; Buss, Claudia; Fair, Damien.

In: Nature Neuroscience, 09.04.2018, p. 1-8.

Research output: Contribution to journalArticle

Rudolph, Marc D. ; Graham, Alice M. ; Feczko, Eric ; Miranda Dominguez, Oscar ; Rasmussen, Jerod M. ; Nardos, Rahel ; Entringer, Sonja ; Wadhwa, Pathik D. ; Buss, Claudia ; Fair, Damien. / Maternal IL-6 during pregnancy can be estimated from newborn brain connectivity and predicts future working memory in offspring. In: Nature Neuroscience. 2018 ; pp. 1-8.
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