Mapping the surface properties of macromolecules

Research output: Contribution to journalArticle

43 Citations (Scopus)

Abstract

Methods are presented for the rapid computation of schematic projections of the surfaces of macromolecules, similar to the 'roadmaps' used to illustrate the surfaces of viruses (Rossmann, M.G. and Palmenberg, A.C., 1988, Virology 164, 373-382). Several types of projections are described, extending the application of 'roadmaps' to the external surfaces of all macromolecules and their interior binding pockets and pores. The surface projections, showing the positions of residues, can be colored, shaded, contoured, and annotated to show physical, sequence, or functional properties such as surface topology, hydrophobicity, or sequence conservation, for example. The automated procedures are useful for surveys of the surface features of proteins sharing similar functional properties.

Original languageEnglish (US)
Pages (from-to)459-469
Number of pages11
JournalProtein Science
Volume2
Issue number3
StatePublished - 1993
Externally publishedYes

Fingerprint

Surface Properties
Macromolecules
Surface properties
Virology
Hydrophobic and Hydrophilic Interactions
Membrane Proteins
Viruses
Schematic diagrams
Hydrophobicity
Conservation
Topology
Surveys and Questionnaires

ASJC Scopus subject areas

  • Biochemistry

Cite this

Mapping the surface properties of macromolecules. / Chapman, Michael.

In: Protein Science, Vol. 2, No. 3, 1993, p. 459-469.

Research output: Contribution to journalArticle

@article{3b2c9570af994b2b9926e7e508924a86,
title = "Mapping the surface properties of macromolecules",
abstract = "Methods are presented for the rapid computation of schematic projections of the surfaces of macromolecules, similar to the 'roadmaps' used to illustrate the surfaces of viruses (Rossmann, M.G. and Palmenberg, A.C., 1988, Virology 164, 373-382). Several types of projections are described, extending the application of 'roadmaps' to the external surfaces of all macromolecules and their interior binding pockets and pores. The surface projections, showing the positions of residues, can be colored, shaded, contoured, and annotated to show physical, sequence, or functional properties such as surface topology, hydrophobicity, or sequence conservation, for example. The automated procedures are useful for surveys of the surface features of proteins sharing similar functional properties.",
author = "Michael Chapman",
year = "1993",
language = "English (US)",
volume = "2",
pages = "459--469",
journal = "Protein Science",
issn = "0961-8368",
publisher = "Cold Spring Harbor Laboratory Press",
number = "3",

}

TY - JOUR

T1 - Mapping the surface properties of macromolecules

AU - Chapman, Michael

PY - 1993

Y1 - 1993

N2 - Methods are presented for the rapid computation of schematic projections of the surfaces of macromolecules, similar to the 'roadmaps' used to illustrate the surfaces of viruses (Rossmann, M.G. and Palmenberg, A.C., 1988, Virology 164, 373-382). Several types of projections are described, extending the application of 'roadmaps' to the external surfaces of all macromolecules and their interior binding pockets and pores. The surface projections, showing the positions of residues, can be colored, shaded, contoured, and annotated to show physical, sequence, or functional properties such as surface topology, hydrophobicity, or sequence conservation, for example. The automated procedures are useful for surveys of the surface features of proteins sharing similar functional properties.

AB - Methods are presented for the rapid computation of schematic projections of the surfaces of macromolecules, similar to the 'roadmaps' used to illustrate the surfaces of viruses (Rossmann, M.G. and Palmenberg, A.C., 1988, Virology 164, 373-382). Several types of projections are described, extending the application of 'roadmaps' to the external surfaces of all macromolecules and their interior binding pockets and pores. The surface projections, showing the positions of residues, can be colored, shaded, contoured, and annotated to show physical, sequence, or functional properties such as surface topology, hydrophobicity, or sequence conservation, for example. The automated procedures are useful for surveys of the surface features of proteins sharing similar functional properties.

UR - http://www.scopus.com/inward/record.url?scp=0027401550&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0027401550&partnerID=8YFLogxK

M3 - Article

C2 - 8384042

AN - SCOPUS:0027401550

VL - 2

SP - 459

EP - 469

JO - Protein Science

JF - Protein Science

SN - 0961-8368

IS - 3

ER -