Abstract
Methods are presented for the rapid computation of schematic projections of the surfaces of macromolecules, similar to the 'roadmaps' used to illustrate the surfaces of viruses (Rossmann, M.G. and Palmenberg, A.C., 1988, Virology 164, 373-382). Several types of projections are described, extending the application of 'roadmaps' to the external surfaces of all macromolecules and their interior binding pockets and pores. The surface projections, showing the positions of residues, can be colored, shaded, contoured, and annotated to show physical, sequence, or functional properties such as surface topology, hydrophobicity, or sequence conservation, for example. The automated procedures are useful for surveys of the surface features of proteins sharing similar functional properties.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 459-469 |
| Number of pages | 11 |
| Journal | Protein Science |
| Volume | 2 |
| Issue number | 3 |
| State | Published - 1993 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Biochemistry
Cite this
Mapping the surface properties of macromolecules. / Chapman, Michael.
In: Protein Science, Vol. 2, No. 3, 1993, p. 459-469.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Mapping the surface properties of macromolecules
AU - Chapman, Michael
PY - 1993
Y1 - 1993
N2 - Methods are presented for the rapid computation of schematic projections of the surfaces of macromolecules, similar to the 'roadmaps' used to illustrate the surfaces of viruses (Rossmann, M.G. and Palmenberg, A.C., 1988, Virology 164, 373-382). Several types of projections are described, extending the application of 'roadmaps' to the external surfaces of all macromolecules and their interior binding pockets and pores. The surface projections, showing the positions of residues, can be colored, shaded, contoured, and annotated to show physical, sequence, or functional properties such as surface topology, hydrophobicity, or sequence conservation, for example. The automated procedures are useful for surveys of the surface features of proteins sharing similar functional properties.
AB - Methods are presented for the rapid computation of schematic projections of the surfaces of macromolecules, similar to the 'roadmaps' used to illustrate the surfaces of viruses (Rossmann, M.G. and Palmenberg, A.C., 1988, Virology 164, 373-382). Several types of projections are described, extending the application of 'roadmaps' to the external surfaces of all macromolecules and their interior binding pockets and pores. The surface projections, showing the positions of residues, can be colored, shaded, contoured, and annotated to show physical, sequence, or functional properties such as surface topology, hydrophobicity, or sequence conservation, for example. The automated procedures are useful for surveys of the surface features of proteins sharing similar functional properties.
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UR - http://www.scopus.com/inward/citedby.url?scp=0027401550&partnerID=8YFLogxK
M3 - Article
C2 - 8384042
AN - SCOPUS:0027401550
VL - 2
SP - 459
EP - 469
JO - Protein Science
JF - Protein Science
SN - 0961-8368
IS - 3
ER -