Mapping the surface properties of macromolecules

Research output: Contribution to journalArticle

44 Scopus citations

Abstract

Methods are presented for the rapid computation of schematic projections of the surfaces of macromolecules, similar to the “roadmaps” used to illustrate the surfaces of viruses (Rossmann, M.G. & Palmenberg, A.C., 1988, Virology 164, 373–382). Several types of projections are described, extending the application of “roadmaps” to the external surfaces of all macromolecules and their interior binding pockets and pores. The surface projections, showing the positions of residues, can be colored, shaded, contoured, and annotated to show physical, sequence, or functional properties such as surface topology, hydrophobicity, or sequence conservation, for example. The automated procedures are useful for surveys of the surface features of proteins sharing similar functional properties.

Original languageEnglish (US)
Pages (from-to)459-469
Number of pages11
JournalProtein Science
Volume2
Issue number3
DOIs
StatePublished - Mar 1993

Keywords

  • graphics
  • macromolecules
  • surface properties

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology

Fingerprint Dive into the research topics of 'Mapping the surface properties of macromolecules'. Together they form a unique fingerprint.

  • Cite this