Management of pregnancy in women with genetic disorders, part 1

Disorders of the connective tissue, muscle, vascular, and skeletal systems

Shilpa Prema Chetty, Brian Shaffer, Mary E. Norton

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Due to early diagnosis and increasingly effective medical advances, the number of women with various genetic syndromes who are undergoing pregnancy is increasing, and this represents an important issue for providers of obstetric care. Each year more women with genetic disease reach childbearing age. Advances in assisted reproductive technology have enabled pregnancy in a cohort of woman who may experience impaired fertility due to their underlying diagnosis. Management of these women requires coordination of care by healthcare providers from multiple specialties to optimize outcomes. Potentially serious medical issues specific to each diagnosis often exist in the preconception, antepartum, intrapartum, and postpartum periods, all of which must be recognized to allow timely diagnosis and treatment. The fetus may also face issues related to risk for inheritance of the genetic disorder itself, as well as risks related to the chronic disease status of the mother. This article will explore the issues faced by women with various genetic disorders that may affect connective tissue, muscular, vascular, and skeletal systems. Target Audience: Obstetricians & Gynecologists and Family Physicians Learning Objectives: After the completing the CME activity, physicians should be better able to classify the cardiovascular manifestations observed in Marfan syndrome and Ehlers-Danlos, evaluate prenatal diagnostic options and limitations for various genetic syndromes, assess the risks to the fetus in women with various genetic syndromes. Determine whether there is a preferred mode of delivery for pregnant patients with various genetic syndromes described in this paper.

Original languageEnglish (US)
Pages (from-to)699-709
Number of pages11
JournalObstetrical and Gynecological Survey
Volume66
Issue number11
DOIs
StatePublished - Nov 2011

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Inborn Genetic Diseases
Connective Tissue
Blood Vessels
Skeletal Muscle
Pregnancy
Fetus
Marfan Syndrome
Assisted Reproductive Techniques
Family Physicians
Health Personnel
Postpartum Period
Obstetrics
Fertility
Early Diagnosis
Chronic Disease
Mothers
Learning
Physicians

ASJC Scopus subject areas

  • Obstetrics and Gynecology

Cite this

Management of pregnancy in women with genetic disorders, part 1 : Disorders of the connective tissue, muscle, vascular, and skeletal systems. / Chetty, Shilpa Prema; Shaffer, Brian; Norton, Mary E.

In: Obstetrical and Gynecological Survey, Vol. 66, No. 11, 11.2011, p. 699-709.

Research output: Contribution to journalArticle

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