Mammalian chromosomes contain cis-acting elements that control replication timing, mitotic condensation, and stability of entire chromosomes

Research output: Contribution to journalReview article

19 Scopus citations

Abstract

Recent studies indicate that mammalian chromosomes contain discrete cis-acting loci that control replication timing, mitotic condensation, and stability of entire chromosomes. Disruption of the large non-coding RNA gene ASAR6 results in late replication, an under-condensed appearance during mitosis, and structural instability of human chromosome 6. Similarly, disruption of the mouse Xist gene in adult somatic cells results in a late replication and instability phenotype on the X chromosome. ASAR6 shares many characteristics with Xist, including random mono-allelic expression and asynchronous replication timing. Additional "chromosome engineering" studies indicate that certain chromosome rearrangements affecting many different chromosomes display this abnormal replication and instability phenotype. These observations suggest that all mammalian chromosomes contain "inactivation/stability centers" that control proper replication, condensation, and stability of individual chromosomes.

Original languageEnglish (US)
Pages (from-to)760-770
Number of pages11
JournalBioEssays
Volume34
Issue number9
DOIs
StatePublished - Sep 2012

Keywords

  • Chromosome pulverization
  • Chromosome structure
  • Genome stability
  • Non-coding RNA
  • Replication timing

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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