Magnetic resonance imaging correlates of clinical outcomes in early multiple sclerosis

Amir Hadi Maghzi, Nisha Revirajan, Laura J. Julian, Rebecca Spain, Ellen M. Mowry, Shuang Liu, Chengshi Jin, Ari J. Green, Charles E. McCulloch, Daniel Pelletier, Emmanuelle Waubant

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Objectives: To study the association between changes in brain magnetic resonance imaging (MRI) and clinical outcomes in early MS. Methods: MS patients within 12 months of onset were enrolled and followed up to 3 years. Clinical measures included Symbol Digit Modalities Test (SDMT), MS Functional Composite (MSFC) and low contrast letter acuity (LCLA). MR] outcomes included brain volume changes measured by SIENA and SIENAX normalized measurements [brain parenchymal volume (BPV), normal-appearing white and gray matter volume (NAWMV and GMV) and T2 lesion volume (T2LV)]. Mixed model regression measured time trends and associations between imaging and clinical outcome. Results: Forty-three patients were enrolled within 7.5 ±4.9 months of onset. Baseline T2 lesion volume predicted subsequent changes in Paced Auditory Serial Addition Test (PASAT) (p=0.004), whereas baseline measures of atrophy including BPV, GMV, and NAWMV predicted longitudinal changes in MSFC (p=0.016, p=0.040, p=0.021, respectively) and Timed-25 Foot Walk (p

Original languageEnglish (US)
Pages (from-to)720-727
Number of pages8
JournalMultiple Sclerosis and Related Disorders
Volume3
Issue number6
DOIs
StatePublished - 2014

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Multiple Sclerosis
Magnetic Resonance Imaging
Brain
Atrophy
Foot

Keywords

  • Brain atrophy
  • Cognition
  • Magnetic resonance imaging
  • Multiple sclerosis
  • Neuroprotection
  • Outcomes

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology
  • Medicine(all)

Cite this

Magnetic resonance imaging correlates of clinical outcomes in early multiple sclerosis. / Maghzi, Amir Hadi; Revirajan, Nisha; Julian, Laura J.; Spain, Rebecca; Mowry, Ellen M.; Liu, Shuang; Jin, Chengshi; Green, Ari J.; McCulloch, Charles E.; Pelletier, Daniel; Waubant, Emmanuelle.

In: Multiple Sclerosis and Related Disorders, Vol. 3, No. 6, 2014, p. 720-727.

Research output: Contribution to journalArticle

Maghzi, AH, Revirajan, N, Julian, LJ, Spain, R, Mowry, EM, Liu, S, Jin, C, Green, AJ, McCulloch, CE, Pelletier, D & Waubant, E 2014, 'Magnetic resonance imaging correlates of clinical outcomes in early multiple sclerosis', Multiple Sclerosis and Related Disorders, vol. 3, no. 6, pp. 720-727. https://doi.org/10.1016/j.msard.2014.07.003
Maghzi, Amir Hadi ; Revirajan, Nisha ; Julian, Laura J. ; Spain, Rebecca ; Mowry, Ellen M. ; Liu, Shuang ; Jin, Chengshi ; Green, Ari J. ; McCulloch, Charles E. ; Pelletier, Daniel ; Waubant, Emmanuelle. / Magnetic resonance imaging correlates of clinical outcomes in early multiple sclerosis. In: Multiple Sclerosis and Related Disorders. 2014 ; Vol. 3, No. 6. pp. 720-727.
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