Macrophages and Metabolism in the Tumor Microenvironment

Ilio Vitale; Gwenola Manic; Lisa M. Coussens; Guido Kroemer; Lorenzo Galluzzi

doi:10.1016/j.cmet.2019.06.001

Macrophages and Metabolism in the Tumor Microenvironment

Ilio Vitale, Gwenola Manic, Lisa M. Coussens, Guido Kroemer, Lorenzo Galluzzi

Cell, Developmental, & Cancer Biology

Research output: Contribution to journal › Review article

21 Scopus citations

Abstract

Vitale et al. discuss the metabolic circuitries whereby tumor-associated macrophages condition their microenvironment to support the cancer growth, metastatic dissemination and resistance to treatment, and how such pathways can be therapeutically targeted.

Original language	English (US)
Pages (from-to)	36-50
Number of pages	15
Journal	Cell Metabolism
Volume	30
Issue number	1
DOIs	https://doi.org/10.1016/j.cmet.2019.06.001
State	Published - Jul 2 2019

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Keywords

fatty acid oxidation
glycolysis
hypoxia
immunosuppressive metabolites
immunotherapy
oxidative phosphorylation

ASJC Scopus subject areas

Physiology
Molecular Biology
Cell Biology

Cite this

Vitale, I., Manic, G., Coussens, L. M., Kroemer, G., & Galluzzi, L. (2019). Macrophages and Metabolism in the Tumor Microenvironment. Cell Metabolism, 30(1), 36-50. https://doi.org/10.1016/j.cmet.2019.06.001

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KW - immunotherapy

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Access to Document

10.1016/j.cmet.2019.06.001