Macrophages and Metabolism in the Tumor Microenvironment

Ilio Vitale; Gwenola Manic; Lisa M. Coussens; Guido Kroemer; Lorenzo Galluzzi

doi:10.1016/j.cmet.2019.06.001

Macrophages and Metabolism in the Tumor Microenvironment

Ilio Vitale, Gwenola Manic, Lisa M. Coussens, Guido Kroemer, Lorenzo Galluzzi

Cell Developmental and Cancer Biology

Research output: Contribution to journal › Review article › peer-review

900 Scopus citations

Abstract

Vitale et al. discuss the metabolic circuitries whereby tumor-associated macrophages condition their microenvironment to support the cancer growth, metastatic dissemination and resistance to treatment, and how such pathways can be therapeutically targeted.

Original language	English (US)
Pages (from-to)	36-50
Number of pages	15
Journal	Cell Metabolism
Volume	30
Issue number	1
DOIs	https://doi.org/10.1016/j.cmet.2019.06.001
State	Published - Jul 2 2019

Keywords

fatty acid oxidation
glycolysis
hypoxia
immunosuppressive metabolites
immunotherapy
oxidative phosphorylation

ASJC Scopus subject areas

Physiology
Molecular Biology
Cell Biology

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10.1016/j.cmet.2019.06.001

Cite this

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title = "Macrophages and Metabolism in the Tumor Microenvironment",

abstract = "Vitale et al. discuss the metabolic circuitries whereby tumor-associated macrophages condition their microenvironment to support the cancer growth, metastatic dissemination and resistance to treatment, and how such pathways can be therapeutically targeted.",

keywords = "fatty acid oxidation, glycolysis, hypoxia, immunosuppressive metabolites, immunotherapy, oxidative phosphorylation",

author = "Ilio Vitale and Gwenola Manic and Coussens, {Lisa M.} and Guido Kroemer and Lorenzo Galluzzi",

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year = "2019",

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AU - Vitale, Ilio

AU - Manic, Gwenola

AU - Coussens, Lisa M.

AU - Kroemer, Guido

AU - Galluzzi, Lorenzo

PY - 2019/7/2

Y1 - 2019/7/2

N2 - Vitale et al. discuss the metabolic circuitries whereby tumor-associated macrophages condition their microenvironment to support the cancer growth, metastatic dissemination and resistance to treatment, and how such pathways can be therapeutically targeted.

AB - Vitale et al. discuss the metabolic circuitries whereby tumor-associated macrophages condition their microenvironment to support the cancer growth, metastatic dissemination and resistance to treatment, and how such pathways can be therapeutically targeted.

KW - fatty acid oxidation

KW - glycolysis

KW - hypoxia

KW - immunosuppressive metabolites

KW - immunotherapy

KW - oxidative phosphorylation

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DO - 10.1016/j.cmet.2019.06.001

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JF - Cell Metabolism

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Macrophages and Metabolism in the Tumor Microenvironment

Abstract

Keywords

ASJC Scopus subject areas

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