Macrophages and Metabolism in the Tumor Microenvironment

Ilio Vitale; Gwenola Manic; Lisa M. Coussens; Guido Kroemer; Lorenzo Galluzzi

doi:10.1016/j.cmet.2019.06.001

Macrophages and Metabolism in the Tumor Microenvironment

Ilio Vitale, Gwenola Manic, Lisa M. Coussens, Guido Kroemer, Lorenzo Galluzzi

Cell, Developmental, & Cancer Biology

Research output: Contribution to journal › Review article

32 Scopus citations

Abstract

Vitale et al. discuss the metabolic circuitries whereby tumor-associated macrophages condition their microenvironment to support the cancer growth, metastatic dissemination and resistance to treatment, and how such pathways can be therapeutically targeted.

Original language	English (US)
Pages (from-to)	36-50
Number of pages	15
Journal	Cell Metabolism
Volume	30
Issue number	1
DOIs	https://doi.org/10.1016/j.cmet.2019.06.001
State	Published - Jul 2 2019

Keywords

fatty acid oxidation
glycolysis
hypoxia
immunosuppressive metabolites
immunotherapy
oxidative phosphorylation

ASJC Scopus subject areas

Physiology
Molecular Biology
Cell Biology

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10.1016/j.cmet.2019.06.001

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Vitale, I., Manic, G., Coussens, L. M., Kroemer, G., & Galluzzi, L. (2019). Macrophages and Metabolism in the Tumor Microenvironment. Cell Metabolism, 30(1), 36-50. https://doi.org/10.1016/j.cmet.2019.06.001

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KW - immunotherapy

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