Lymphotropic nanoparticle-enhanced magnetic resonance imaging (LNMRI) identifies occult lymph node metastases in prostate cancer patients prior to salvage radiation therapy

Robert W. Ross; Anthony L. Zietman; Wanling Xie; John J. Coen; Douglas M. Dahl; William U. Shipley; Donald S. Kaufman; Tina Islam; Alexander R. Guimaraes; Ralph Weissleder; Mukesh Harisinghani

doi:10.1016/j.clinimag.2009.01.013

Lymphotropic nanoparticle-enhanced magnetic resonance imaging (LNMRI) identifies occult lymph node metastases in prostate cancer patients prior to salvage radiation therapy

Robert W. Ross, Anthony L. Zietman, Wanling Xie, John J. Coen, Douglas M. Dahl, William U. Shipley, Donald S. Kaufman, Tina Islam, Alexander R. Guimaraes, Ralph Weissleder, Mukesh Harisinghani

Research output: Contribution to journal › Article › peer-review

83 Scopus citations

Abstract

Twenty-six patients with prostate cancer status post-radical prostatectomy who were candidates for salvage radiation therapy (SRT) underwent lymphotropic nanoparticle enhanced MRI (LNMRI) using superparamagnetic nanoparticle ferumoxtran-10. LNMRI was well tolerated, with only two adverse events, both Grade 2. Six (23%) of the 26 patients, previously believed to be node negative, tested lymph node positive by LNMRI. A total of nine positive lymph nodes were identified in these six patients, none of which were enlarged based on size criteria.

Original language	English (US)
Pages (from-to)	301-305
Number of pages	5
Journal	Clinical Imaging
Volume	33
Issue number	4
DOIs	https://doi.org/10.1016/j.clinimag.2009.01.013
State	Published - Jul 2009
Externally published	Yes

Keywords

Ferumoxtran-10
Lymph nodes
Metastases
Nanoparticle MR imaging
Salvage radiation therapy

ASJC Scopus subject areas

Radiology Nuclear Medicine and imaging

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10.1016/j.clinimag.2009.01.013

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Ross, R. W., Zietman, A. L., Xie, W., Coen, J. J., Dahl, D. M., Shipley, W. U., Kaufman, D. S., Islam, T., Guimaraes, A. R., Weissleder, R., & Harisinghani, M. (2009). Lymphotropic nanoparticle-enhanced magnetic resonance imaging (LNMRI) identifies occult lymph node metastases in prostate cancer patients prior to salvage radiation therapy. Clinical Imaging, 33(4), 301-305. https://doi.org/10.1016/j.clinimag.2009.01.013

Ross, RW, Zietman, AL, Xie, W, Coen, JJ, Dahl, DM, Shipley, WU, Kaufman, DS, Islam, T, Guimaraes, AR, Weissleder, R & Harisinghani, M 2009, 'Lymphotropic nanoparticle-enhanced magnetic resonance imaging (LNMRI) identifies occult lymph node metastases in prostate cancer patients prior to salvage radiation therapy', Clinical Imaging, vol. 33, no. 4, pp. 301-305. https://doi.org/10.1016/j.clinimag.2009.01.013

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title = "Lymphotropic nanoparticle-enhanced magnetic resonance imaging (LNMRI) identifies occult lymph node metastases in prostate cancer patients prior to salvage radiation therapy",

abstract = "Twenty-six patients with prostate cancer status post-radical prostatectomy who were candidates for salvage radiation therapy (SRT) underwent lymphotropic nanoparticle enhanced MRI (LNMRI) using superparamagnetic nanoparticle ferumoxtran-10. LNMRI was well tolerated, with only two adverse events, both Grade 2. Six (23%) of the 26 patients, previously believed to be node negative, tested lymph node positive by LNMRI. A total of nine positive lymph nodes were identified in these six patients, none of which were enlarged based on size criteria.",

keywords = "Ferumoxtran-10, Lymph nodes, Metastases, Nanoparticle MR imaging, Salvage radiation therapy",

author = "Ross, {Robert W.} and Zietman, {Anthony L.} and Wanling Xie and Coen, {John J.} and Dahl, {Douglas M.} and Shipley, {William U.} and Kaufman, {Donald S.} and Tina Islam and Guimaraes, {Alexander R.} and Ralph Weissleder and Mukesh Harisinghani",

note = "Funding Information: Support provided by the Bertucci Foundation and an American Society of Clinical Oncology Career Development Award (to RWR). Imaging agent provided by AMAG Pharmaceuticals, Inc. (Cambridge, MA, USA). No conflicts of interest are reported. ",

year = "2009",

month = jul,

doi = "10.1016/j.clinimag.2009.01.013",

language = "English (US)",

volume = "33",

pages = "301--305",

journal = "Clinical Imaging",

issn = "0899-7071",

publisher = "Elsevier Inc.",

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T1 - Lymphotropic nanoparticle-enhanced magnetic resonance imaging (LNMRI) identifies occult lymph node metastases in prostate cancer patients prior to salvage radiation therapy

AU - Ross, Robert W.

AU - Zietman, Anthony L.

AU - Xie, Wanling

AU - Coen, John J.

AU - Dahl, Douglas M.

AU - Shipley, William U.

AU - Kaufman, Donald S.

AU - Islam, Tina

AU - Guimaraes, Alexander R.

AU - Weissleder, Ralph

AU - Harisinghani, Mukesh

N1 - Funding Information: Support provided by the Bertucci Foundation and an American Society of Clinical Oncology Career Development Award (to RWR). Imaging agent provided by AMAG Pharmaceuticals, Inc. (Cambridge, MA, USA). No conflicts of interest are reported.

PY - 2009/7

Y1 - 2009/7

N2 - Twenty-six patients with prostate cancer status post-radical prostatectomy who were candidates for salvage radiation therapy (SRT) underwent lymphotropic nanoparticle enhanced MRI (LNMRI) using superparamagnetic nanoparticle ferumoxtran-10. LNMRI was well tolerated, with only two adverse events, both Grade 2. Six (23%) of the 26 patients, previously believed to be node negative, tested lymph node positive by LNMRI. A total of nine positive lymph nodes were identified in these six patients, none of which were enlarged based on size criteria.

AB - Twenty-six patients with prostate cancer status post-radical prostatectomy who were candidates for salvage radiation therapy (SRT) underwent lymphotropic nanoparticle enhanced MRI (LNMRI) using superparamagnetic nanoparticle ferumoxtran-10. LNMRI was well tolerated, with only two adverse events, both Grade 2. Six (23%) of the 26 patients, previously believed to be node negative, tested lymph node positive by LNMRI. A total of nine positive lymph nodes were identified in these six patients, none of which were enlarged based on size criteria.

KW - Ferumoxtran-10

KW - Lymph nodes

KW - Metastases

KW - Nanoparticle MR imaging

KW - Salvage radiation therapy

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Lymphotropic nanoparticle-enhanced magnetic resonance imaging (LNMRI) identifies occult lymph node metastases in prostate cancer patients prior to salvage radiation therapy

Abstract

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ASJC Scopus subject areas

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