Lymphotropic nanoparticle-enhanced magnetic resonance imaging (LNMRI) identifies occult lymph node metastases in prostate cancer patients prior to salvage radiation therapy

Robert W. Ross, Anthony L. Zietman, Wanling Xie, John J. Coen, Douglas M. Dahl, William U. Shipley, Donald S. Kaufman, Tina Islam, Alexander Guimaraes, Ralph Weissleder, Mukesh Harisinghani

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Twenty-six patients with prostate cancer status post-radical prostatectomy who were candidates for salvage radiation therapy (SRT) underwent lymphotropic nanoparticle enhanced MRI (LNMRI) using superparamagnetic nanoparticle ferumoxtran-10. LNMRI was well tolerated, with only two adverse events, both Grade 2. Six (23%) of the 26 patients, previously believed to be node negative, tested lymph node positive by LNMRI. A total of nine positive lymph nodes were identified in these six patients, none of which were enlarged based on size criteria.

Original languageEnglish (US)
Pages (from-to)301-305
Number of pages5
JournalClinical Imaging
Issue number4
Publication statusPublished - Jul 2009
Externally publishedYes



  • Ferumoxtran-10
  • Lymph nodes
  • Metastases
  • Nanoparticle MR imaging
  • Salvage radiation therapy

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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