Lutein is differentially deposited across brain regions following formula or breast feeding of infant rhesus macaques

Sookyoung Jeon, Katherine M. Ranard, Martha Neuringer, Emily E. Johnson, Lauren Renner, Matthew J. Kuchan, Suzette L. Pereira, Elizabeth J. Johnson, John W. Erdman

    Research output: Contribution to journalLetter

    9 Citations (Scopus)

    Abstract

    Background: Lutein, a yellow xanthophyll, selectively accumulates in primate retina and brain. Lutein may play a critical role in neural and retinal development, but few studies have investigated the impact of dietary source on its bioaccumulation in infants. Objective: We explored the bioaccumulation of lutein in infant rhesus macaques following breastfeeding or formulafeeding. Methods: From birth to 6 mo of age, male and female rhesus macaques (Macaca mulatta) were either breastfed (BF) (n = 8), fed a formula supplemented with lutein, zeaxanthin, β-carotene, and lycopene (237, 19.0, 74.2, and 338 nmol/kg, supplemented formula-fed; SF) (n = 8), or fed a formula with low amounts of these carotenoids (38.6, 2.3, 21.5, and 0 nmol/kg, unsupplemented formula-fed; UF) (n = 7). The concentrations of carotenoids in serum and tissues were analyzed by HPLC. Results: At 6 mo of age, the BF group exhibited significantly higher lutein concentrations in serum, all brain regions, macular and peripheral retina, adipose tissue, liver, and other tissues compared to both formula-fed groups (P < 0.001). Lutein concentrations were higher in the SF group than in the UF group in serum and all tissues, with the exception of macular retina. Lutein was differentially distributed across brain areas, with the highest concentrations in the occipital cortex, regardless of the diet. Zeaxanthin was present in all brain regions but only in the BF infants; it was present in both retinal regions in all groups but was significantly enhanced in BF infants compared to either formula group (P < 0.001). β-Carotene accumulated across brain regions in all groups, butwas not detected in retina. Although lycopene was found in many tissues of the SF group, it was not detected in the brain or retina. Conclusions: Although carotenoid supplementation of infant formula significantly increased serum and tissue lutein concentrations compared to unsupplemented formula, concentrations were still well below those in BF infants. Regardless of diet, occipital cortex showed selectively higher lutein deposition than other brain regions, suggesting lutein's role in visual processing in early life.

    Original languageEnglish (US)
    Pages (from-to)31-39
    Number of pages9
    JournalJournal of Nutrition
    Volume148
    Issue number1
    DOIs
    StatePublished - Jan 1 2018

    Fingerprint

    Lutein
    Breast Feeding
    Macaca mulatta
    Brain
    Carotenoids
    Retina
    Occipital Lobe
    Serum
    Xanthophylls
    Diet
    Infant Formula
    Primates
    Adipose Tissue
    Age Groups
    High Pressure Liquid Chromatography
    Parturition

    Keywords

    • Bioaccumulation
    • Brain
    • Breast milk
    • Carotenoids
    • Infant formula
    • Infants
    • Lutein
    • Retina
    • Rhesus macaques

    ASJC Scopus subject areas

    • Medicine (miscellaneous)
    • Nutrition and Dietetics

    Cite this

    Lutein is differentially deposited across brain regions following formula or breast feeding of infant rhesus macaques. / Jeon, Sookyoung; Ranard, Katherine M.; Neuringer, Martha; Johnson, Emily E.; Renner, Lauren; Kuchan, Matthew J.; Pereira, Suzette L.; Johnson, Elizabeth J.; Erdman, John W.

    In: Journal of Nutrition, Vol. 148, No. 1, 01.01.2018, p. 31-39.

    Research output: Contribution to journalLetter

    Jeon, S, Ranard, KM, Neuringer, M, Johnson, EE, Renner, L, Kuchan, MJ, Pereira, SL, Johnson, EJ & Erdman, JW 2018, 'Lutein is differentially deposited across brain regions following formula or breast feeding of infant rhesus macaques', Journal of Nutrition, vol. 148, no. 1, pp. 31-39. https://doi.org/10.1093/jn/nxx023
    Jeon, Sookyoung ; Ranard, Katherine M. ; Neuringer, Martha ; Johnson, Emily E. ; Renner, Lauren ; Kuchan, Matthew J. ; Pereira, Suzette L. ; Johnson, Elizabeth J. ; Erdman, John W. / Lutein is differentially deposited across brain regions following formula or breast feeding of infant rhesus macaques. In: Journal of Nutrition. 2018 ; Vol. 148, No. 1. pp. 31-39.
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    title = "Lutein is differentially deposited across brain regions following formula or breast feeding of infant rhesus macaques",
    abstract = "Background: Lutein, a yellow xanthophyll, selectively accumulates in primate retina and brain. Lutein may play a critical role in neural and retinal development, but few studies have investigated the impact of dietary source on its bioaccumulation in infants. Objective: We explored the bioaccumulation of lutein in infant rhesus macaques following breastfeeding or formulafeeding. Methods: From birth to 6 mo of age, male and female rhesus macaques (Macaca mulatta) were either breastfed (BF) (n = 8), fed a formula supplemented with lutein, zeaxanthin, β-carotene, and lycopene (237, 19.0, 74.2, and 338 nmol/kg, supplemented formula-fed; SF) (n = 8), or fed a formula with low amounts of these carotenoids (38.6, 2.3, 21.5, and 0 nmol/kg, unsupplemented formula-fed; UF) (n = 7). The concentrations of carotenoids in serum and tissues were analyzed by HPLC. Results: At 6 mo of age, the BF group exhibited significantly higher lutein concentrations in serum, all brain regions, macular and peripheral retina, adipose tissue, liver, and other tissues compared to both formula-fed groups (P < 0.001). Lutein concentrations were higher in the SF group than in the UF group in serum and all tissues, with the exception of macular retina. Lutein was differentially distributed across brain areas, with the highest concentrations in the occipital cortex, regardless of the diet. Zeaxanthin was present in all brain regions but only in the BF infants; it was present in both retinal regions in all groups but was significantly enhanced in BF infants compared to either formula group (P < 0.001). β-Carotene accumulated across brain regions in all groups, butwas not detected in retina. Although lycopene was found in many tissues of the SF group, it was not detected in the brain or retina. Conclusions: Although carotenoid supplementation of infant formula significantly increased serum and tissue lutein concentrations compared to unsupplemented formula, concentrations were still well below those in BF infants. Regardless of diet, occipital cortex showed selectively higher lutein deposition than other brain regions, suggesting lutein's role in visual processing in early life.",
    keywords = "Bioaccumulation, Brain, Breast milk, Carotenoids, Infant formula, Infants, Lutein, Retina, Rhesus macaques",
    author = "Sookyoung Jeon and Ranard, {Katherine M.} and Martha Neuringer and Johnson, {Emily E.} and Lauren Renner and Kuchan, {Matthew J.} and Pereira, {Suzette L.} and Johnson, {Elizabeth J.} and Erdman, {John W.}",
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    TY - JOUR

    T1 - Lutein is differentially deposited across brain regions following formula or breast feeding of infant rhesus macaques

    AU - Jeon, Sookyoung

    AU - Ranard, Katherine M.

    AU - Neuringer, Martha

    AU - Johnson, Emily E.

    AU - Renner, Lauren

    AU - Kuchan, Matthew J.

    AU - Pereira, Suzette L.

    AU - Johnson, Elizabeth J.

    AU - Erdman, John W.

    PY - 2018/1/1

    Y1 - 2018/1/1

    N2 - Background: Lutein, a yellow xanthophyll, selectively accumulates in primate retina and brain. Lutein may play a critical role in neural and retinal development, but few studies have investigated the impact of dietary source on its bioaccumulation in infants. Objective: We explored the bioaccumulation of lutein in infant rhesus macaques following breastfeeding or formulafeeding. Methods: From birth to 6 mo of age, male and female rhesus macaques (Macaca mulatta) were either breastfed (BF) (n = 8), fed a formula supplemented with lutein, zeaxanthin, β-carotene, and lycopene (237, 19.0, 74.2, and 338 nmol/kg, supplemented formula-fed; SF) (n = 8), or fed a formula with low amounts of these carotenoids (38.6, 2.3, 21.5, and 0 nmol/kg, unsupplemented formula-fed; UF) (n = 7). The concentrations of carotenoids in serum and tissues were analyzed by HPLC. Results: At 6 mo of age, the BF group exhibited significantly higher lutein concentrations in serum, all brain regions, macular and peripheral retina, adipose tissue, liver, and other tissues compared to both formula-fed groups (P < 0.001). Lutein concentrations were higher in the SF group than in the UF group in serum and all tissues, with the exception of macular retina. Lutein was differentially distributed across brain areas, with the highest concentrations in the occipital cortex, regardless of the diet. Zeaxanthin was present in all brain regions but only in the BF infants; it was present in both retinal regions in all groups but was significantly enhanced in BF infants compared to either formula group (P < 0.001). β-Carotene accumulated across brain regions in all groups, butwas not detected in retina. Although lycopene was found in many tissues of the SF group, it was not detected in the brain or retina. Conclusions: Although carotenoid supplementation of infant formula significantly increased serum and tissue lutein concentrations compared to unsupplemented formula, concentrations were still well below those in BF infants. Regardless of diet, occipital cortex showed selectively higher lutein deposition than other brain regions, suggesting lutein's role in visual processing in early life.

    AB - Background: Lutein, a yellow xanthophyll, selectively accumulates in primate retina and brain. Lutein may play a critical role in neural and retinal development, but few studies have investigated the impact of dietary source on its bioaccumulation in infants. Objective: We explored the bioaccumulation of lutein in infant rhesus macaques following breastfeeding or formulafeeding. Methods: From birth to 6 mo of age, male and female rhesus macaques (Macaca mulatta) were either breastfed (BF) (n = 8), fed a formula supplemented with lutein, zeaxanthin, β-carotene, and lycopene (237, 19.0, 74.2, and 338 nmol/kg, supplemented formula-fed; SF) (n = 8), or fed a formula with low amounts of these carotenoids (38.6, 2.3, 21.5, and 0 nmol/kg, unsupplemented formula-fed; UF) (n = 7). The concentrations of carotenoids in serum and tissues were analyzed by HPLC. Results: At 6 mo of age, the BF group exhibited significantly higher lutein concentrations in serum, all brain regions, macular and peripheral retina, adipose tissue, liver, and other tissues compared to both formula-fed groups (P < 0.001). Lutein concentrations were higher in the SF group than in the UF group in serum and all tissues, with the exception of macular retina. Lutein was differentially distributed across brain areas, with the highest concentrations in the occipital cortex, regardless of the diet. Zeaxanthin was present in all brain regions but only in the BF infants; it was present in both retinal regions in all groups but was significantly enhanced in BF infants compared to either formula group (P < 0.001). β-Carotene accumulated across brain regions in all groups, butwas not detected in retina. Although lycopene was found in many tissues of the SF group, it was not detected in the brain or retina. Conclusions: Although carotenoid supplementation of infant formula significantly increased serum and tissue lutein concentrations compared to unsupplemented formula, concentrations were still well below those in BF infants. Regardless of diet, occipital cortex showed selectively higher lutein deposition than other brain regions, suggesting lutein's role in visual processing in early life.

    KW - Bioaccumulation

    KW - Brain

    KW - Breast milk

    KW - Carotenoids

    KW - Infant formula

    KW - Infants

    KW - Lutein

    KW - Retina

    KW - Rhesus macaques

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