Lutein and brain function

John W. Erdman, Joshua W. Smith, Matthew J. Kuchan, Emily S. Mohn, Elizabeth J. Johnson, Stanislav S. Rubakhin, Lin Wang, Jonathan V. Sweedler, Martha Neuringer

    Research output: Contribution to journalArticlepeer-review

    69 Scopus citations


    Lutein is one of the most prevalent carotenoids in nature and in the human diet. Together with zeaxanthin, it is highly concentrated as macular pigment in the foveal retina of primates, attenuating blue light exposure, providing protection from photo-oxidation and enhancing visual performance. Recently, interest in lutein has expanded beyond the retina to its possible contributions to brain development and function. Only primates accumulate lutein within the brain, but little is known about its distribution or physiological role. Our team has begun to utilize the rhesus macaque (Macaca mulatta) model to study the uptake and bio-localization of lutein in the brain. Our overall goal has been to assess the association of lutein localization with brain function. In this review, we will first cover the evolution of the non-human primate model for lutein and brain studies, discuss prior association studies of lutein with retina and brain function, and review approaches that can be used to localize brain lutein. We also describe our approach to the biosynthesis of13C-lutein, which will allow investigation of lutein flux, localization, metabolism and pharmacokinetics. Lastly, we describe potential future research opportunities.

    Original languageEnglish (US)
    Pages (from-to)547-564
    Number of pages18
    Issue number4
    StatePublished - Dec 2015


    • Animal models
    • Brain function
    • Carotenoids
    • Lutein
    • Monkeys

    ASJC Scopus subject areas

    • Food Science
    • Microbiology
    • Health(social science)
    • Health Professions (miscellaneous)
    • Plant Science


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