TY - JOUR
T1 - Lung function and mortality in the United States
T2 - Data from the First National Health and Nutrition Examination Survey follow up study
AU - Mannino, D. M.
AU - Buist, A. S.
AU - Petty, T. L.
AU - Enright, P. L.
AU - Redd, S. C.
PY - 2003/5/1
Y1 - 2003/5/1
N2 - Background: A study was undertaken to define the risk of death among a national cohort of US adults both with and without lung disease. Methods: Participants in the first National Health and Nutrition Examination Survey (NHANES I) followed for up to 22 years were studied. Subjects were classified using a modification of the Global Initiative for Chronic Obstructive Lung Disease criteria for chronic obstructive pulmonary disease (COPD) into the following mutually exclusive categories using the forced expiratory volume in 1 second (FEV1), forced vital capacity (FVC), FEV1/FVC ratio, and the presence of respiratory symptoms: severe COPD, moderate COPD, mild COPD, respiratory symptoms only, restrictive lung disease, and no lung disease. Proportional hazard models were developed that controlled for age, race, sex, education, smoking status, pack years of smoking, years since quitting smoking, and body mass index. Results: A total of 1301 deaths occurred in the 5542 adults in the cohort. In the adjusted proportional hazards model the presence of severe or moderate COPD was associated with a higher risk of death (hazard ratios (HR) 2.7 and 1.6, 95% confidence intervals (Cl) 2.1 to 3.5 and 1.4 to 2.0), as was restrictive lung disease (HR 1.7, 95% Cl 1.4 to 2.0). Conclusions: The presence of both obstructive and restrictive lung disease is a significant predictor of earlier death in long term follow up.
AB - Background: A study was undertaken to define the risk of death among a national cohort of US adults both with and without lung disease. Methods: Participants in the first National Health and Nutrition Examination Survey (NHANES I) followed for up to 22 years were studied. Subjects were classified using a modification of the Global Initiative for Chronic Obstructive Lung Disease criteria for chronic obstructive pulmonary disease (COPD) into the following mutually exclusive categories using the forced expiratory volume in 1 second (FEV1), forced vital capacity (FVC), FEV1/FVC ratio, and the presence of respiratory symptoms: severe COPD, moderate COPD, mild COPD, respiratory symptoms only, restrictive lung disease, and no lung disease. Proportional hazard models were developed that controlled for age, race, sex, education, smoking status, pack years of smoking, years since quitting smoking, and body mass index. Results: A total of 1301 deaths occurred in the 5542 adults in the cohort. In the adjusted proportional hazards model the presence of severe or moderate COPD was associated with a higher risk of death (hazard ratios (HR) 2.7 and 1.6, 95% confidence intervals (Cl) 2.1 to 3.5 and 1.4 to 2.0), as was restrictive lung disease (HR 1.7, 95% Cl 1.4 to 2.0). Conclusions: The presence of both obstructive and restrictive lung disease is a significant predictor of earlier death in long term follow up.
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U2 - 10.1136/thorax.58.5.388
DO - 10.1136/thorax.58.5.388
M3 - Article
C2 - 12728157
AN - SCOPUS:0038752573
SN - 0040-6376
VL - 58
SP - 388
EP - 393
JO - Thorax
JF - Thorax
IS - 5
ER -