Luminal influences on potassium secretion

Chloride, sodium, and thiazide diuretics

Heino Velázquez, David Ellison, Fred S. Wright

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

In the presence of Cl-, K+ secretion by the distal tubule saturates with increasing luminal Na+ concentration. Apparent maximal K+ secretion is attained with luminal Na+ concentrations of 40 mM. The results of the present study show that lowering the Cl- concentration of luminal fluid can increase the level of Na+-stimulated K+ secretion beyond the maximal level attained in the presence of Cl-. The effect of lowering luminal Cl- concentration to + secretion is greater with higher Na+ concentration. Under these conditions, chlorothiazide decreases K+ secretion. When chlorothiazide is present, changing the Na+ concentration does not affect K+ secretion. Because in rats a thiazide effect is attributed primarily to the distal convoluted tubule (DCT), we postulate that it is primarily DCT cells that increase K+ secretion when Na+ concentration is raised in the presence of low luminal Cl- concentration. We propose that the rat DCT cells have both an absorptive Na+-Cl- cotransport mechanism and a secretory K+-Cl- cotransport mechanism in the luminal membrane that can mediate the apparent exchange of Na+ for K+.

Original languageEnglish (US)
JournalAmerican Journal of Physiology - Renal Fluid and Electrolyte Physiology
Volume262
Issue number6 31-6
StatePublished - 1992
Externally publishedYes

Fingerprint

Chlorothiazide
Sodium Chloride Symporter Inhibitors
Potassium Chloride
Sodium
Thiazides
Membranes

Keywords

  • Chlorothiazide
  • Distal convoluted tubule
  • Gluconate
  • Kidney
  • Potassium-chloride cotransport
  • Rat
  • Sodium-chloride cotransport
  • Transport

ASJC Scopus subject areas

  • Physiology

Cite this

Luminal influences on potassium secretion : Chloride, sodium, and thiazide diuretics. / Velázquez, Heino; Ellison, David; Wright, Fred S.

In: American Journal of Physiology - Renal Fluid and Electrolyte Physiology, Vol. 262, No. 6 31-6, 1992.

Research output: Contribution to journalArticle

@article{d41214bcd33a47b9be1ca9e3af359527,
title = "Luminal influences on potassium secretion: Chloride, sodium, and thiazide diuretics",
abstract = "In the presence of Cl-, K+ secretion by the distal tubule saturates with increasing luminal Na+ concentration. Apparent maximal K+ secretion is attained with luminal Na+ concentrations of 40 mM. The results of the present study show that lowering the Cl- concentration of luminal fluid can increase the level of Na+-stimulated K+ secretion beyond the maximal level attained in the presence of Cl-. The effect of lowering luminal Cl- concentration to + secretion is greater with higher Na+ concentration. Under these conditions, chlorothiazide decreases K+ secretion. When chlorothiazide is present, changing the Na+ concentration does not affect K+ secretion. Because in rats a thiazide effect is attributed primarily to the distal convoluted tubule (DCT), we postulate that it is primarily DCT cells that increase K+ secretion when Na+ concentration is raised in the presence of low luminal Cl- concentration. We propose that the rat DCT cells have both an absorptive Na+-Cl- cotransport mechanism and a secretory K+-Cl- cotransport mechanism in the luminal membrane that can mediate the apparent exchange of Na+ for K+.",
keywords = "Chlorothiazide, Distal convoluted tubule, Gluconate, Kidney, Potassium-chloride cotransport, Rat, Sodium-chloride cotransport, Transport",
author = "Heino Vel{\'a}zquez and David Ellison and Wright, {Fred S.}",
year = "1992",
language = "English (US)",
volume = "262",
journal = "American Journal of Physiology - Renal Fluid and Electrolyte Physiology",
issn = "1931-857X",
publisher = "American Physiological Society",
number = "6 31-6",

}

TY - JOUR

T1 - Luminal influences on potassium secretion

T2 - Chloride, sodium, and thiazide diuretics

AU - Velázquez, Heino

AU - Ellison, David

AU - Wright, Fred S.

PY - 1992

Y1 - 1992

N2 - In the presence of Cl-, K+ secretion by the distal tubule saturates with increasing luminal Na+ concentration. Apparent maximal K+ secretion is attained with luminal Na+ concentrations of 40 mM. The results of the present study show that lowering the Cl- concentration of luminal fluid can increase the level of Na+-stimulated K+ secretion beyond the maximal level attained in the presence of Cl-. The effect of lowering luminal Cl- concentration to + secretion is greater with higher Na+ concentration. Under these conditions, chlorothiazide decreases K+ secretion. When chlorothiazide is present, changing the Na+ concentration does not affect K+ secretion. Because in rats a thiazide effect is attributed primarily to the distal convoluted tubule (DCT), we postulate that it is primarily DCT cells that increase K+ secretion when Na+ concentration is raised in the presence of low luminal Cl- concentration. We propose that the rat DCT cells have both an absorptive Na+-Cl- cotransport mechanism and a secretory K+-Cl- cotransport mechanism in the luminal membrane that can mediate the apparent exchange of Na+ for K+.

AB - In the presence of Cl-, K+ secretion by the distal tubule saturates with increasing luminal Na+ concentration. Apparent maximal K+ secretion is attained with luminal Na+ concentrations of 40 mM. The results of the present study show that lowering the Cl- concentration of luminal fluid can increase the level of Na+-stimulated K+ secretion beyond the maximal level attained in the presence of Cl-. The effect of lowering luminal Cl- concentration to + secretion is greater with higher Na+ concentration. Under these conditions, chlorothiazide decreases K+ secretion. When chlorothiazide is present, changing the Na+ concentration does not affect K+ secretion. Because in rats a thiazide effect is attributed primarily to the distal convoluted tubule (DCT), we postulate that it is primarily DCT cells that increase K+ secretion when Na+ concentration is raised in the presence of low luminal Cl- concentration. We propose that the rat DCT cells have both an absorptive Na+-Cl- cotransport mechanism and a secretory K+-Cl- cotransport mechanism in the luminal membrane that can mediate the apparent exchange of Na+ for K+.

KW - Chlorothiazide

KW - Distal convoluted tubule

KW - Gluconate

KW - Kidney

KW - Potassium-chloride cotransport

KW - Rat

KW - Sodium-chloride cotransport

KW - Transport

UR - http://www.scopus.com/inward/record.url?scp=0026780205&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0026780205&partnerID=8YFLogxK

M3 - Article

VL - 262

JO - American Journal of Physiology - Renal Fluid and Electrolyte Physiology

JF - American Journal of Physiology - Renal Fluid and Electrolyte Physiology

SN - 1931-857X

IS - 6 31-6

ER -