Low zero-flow pressure and minimal capacitance effect on diastolic coronary arterial pressure-flow relationships during maximum vasodilation in swine

George Pantely, H. D. Ladley, J. D. Bristow

    Research output: Contribution to journalArticle

    30 Citations (Scopus)

    Abstract

    During maximum dilation with adenosine in dogs, the diastolic coronary pressure at which flow ceases (Pzf) has been observed to be up to 27 mm Hg above coronary sinus and right atrial pressures. We studied swine to measure the Pzf and to determine the effects of interventions that change collateral flow and coronary capacitance. In 44 swine, the left anterior descending coronary artery (LAD) was instrumented with two catheters, a hydraulic occluder, and a flowmeter. Late diastolic and mean pressure-flow relationships were constructed at a series of pressures produced by partial LAD occlusions during maximum vasodilation. The late diastolic Pzf was 7.0 ± 2.2 mm Hg (mean ± SD), less than 4 mm Hg above right atrial pressure; the mean Pzf was 12.1 ± 3.1 mm Hg, less than 9 mm Hg above right atrial pressure. The Pzf in the LAD did not change significantly (1) during transient simultaneous occlusion of the right coronary artery (RCA) in seven swine (late diastolic Pzf with the RCA open was 6.6 ± 1.5 mm Hg and with the RCA closed it was 6.0 ± 1.5 mm Hg), (2) during increased left ventricular systolic pressure (LVSP) in seven swine (late diastolic Pzf with LVSP of 123 mm Hg was 5.5 ± 2.2 mm Hg and with LVSP of 184 mm Hg it was 7.3 ± 2.8 mm Hg), or (3) during increased heart rate in eight swine (late diastolic Pzf at heart rate of 107 per minute was 10.8 ± 2.9 mm Hg and at 180 per minute it was 12.7 ± 2.1 mm Hg). similar results were obtained from analysis of the mean pressure and flow data. The Pzf in the LAD of swine is very close to right atrial pressure, and it did not change significantly during interventions that would modify collateral flow (reduced by RCA occlusion and enhanced by increased LVSP) and coronary capacitance (increased LVSP and increased heart rate). This low Pzf is beneficial in maintaining flow at lower coronary arterial perfusion pressures.

    Original languageEnglish (US)
    Pages (from-to)485-494
    Number of pages10
    JournalCirculation
    Volume70
    Issue number3 I
    StatePublished - 1984

    Fingerprint

    Vasodilation
    Arterial Pressure
    Swine
    Ventricular Pressure
    Atrial Pressure
    Blood Pressure
    Pressure
    Coronary Vessels
    Heart Rate
    Flowmeters
    Coronary Sinus
    Partial Pressure
    Coronary Occlusion
    Adenosine
    Dilatation
    Catheters
    Perfusion
    Dogs

    ASJC Scopus subject areas

    • Physiology
    • Cardiology and Cardiovascular Medicine

    Cite this

    Low zero-flow pressure and minimal capacitance effect on diastolic coronary arterial pressure-flow relationships during maximum vasodilation in swine. / Pantely, George; Ladley, H. D.; Bristow, J. D.

    In: Circulation, Vol. 70, No. 3 I, 1984, p. 485-494.

    Research output: Contribution to journalArticle

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    abstract = "During maximum dilation with adenosine in dogs, the diastolic coronary pressure at which flow ceases (Pzf) has been observed to be up to 27 mm Hg above coronary sinus and right atrial pressures. We studied swine to measure the Pzf and to determine the effects of interventions that change collateral flow and coronary capacitance. In 44 swine, the left anterior descending coronary artery (LAD) was instrumented with two catheters, a hydraulic occluder, and a flowmeter. Late diastolic and mean pressure-flow relationships were constructed at a series of pressures produced by partial LAD occlusions during maximum vasodilation. The late diastolic Pzf was 7.0 ± 2.2 mm Hg (mean ± SD), less than 4 mm Hg above right atrial pressure; the mean Pzf was 12.1 ± 3.1 mm Hg, less than 9 mm Hg above right atrial pressure. The Pzf in the LAD did not change significantly (1) during transient simultaneous occlusion of the right coronary artery (RCA) in seven swine (late diastolic Pzf with the RCA open was 6.6 ± 1.5 mm Hg and with the RCA closed it was 6.0 ± 1.5 mm Hg), (2) during increased left ventricular systolic pressure (LVSP) in seven swine (late diastolic Pzf with LVSP of 123 mm Hg was 5.5 ± 2.2 mm Hg and with LVSP of 184 mm Hg it was 7.3 ± 2.8 mm Hg), or (3) during increased heart rate in eight swine (late diastolic Pzf at heart rate of 107 per minute was 10.8 ± 2.9 mm Hg and at 180 per minute it was 12.7 ± 2.1 mm Hg). similar results were obtained from analysis of the mean pressure and flow data. The Pzf in the LAD of swine is very close to right atrial pressure, and it did not change significantly during interventions that would modify collateral flow (reduced by RCA occlusion and enhanced by increased LVSP) and coronary capacitance (increased LVSP and increased heart rate). This low Pzf is beneficial in maintaining flow at lower coronary arterial perfusion pressures.",
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