Low-value approvals and high prices might incentivize ineffective drug development

Vinay Prasad; Christopher McCabe; Sham Mailankody

doi:10.1038/s41571-018-0030-2

Low-value approvals and high prices might incentivize ineffective drug development

Vinay Prasad, Christopher McCabe, Sham Mailankody

Knight Cancer Institute

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

Drug regulators' acceptance of any statistically significant improvement shown in a single randomized trial and lofty drug prices has created a situation where it is now, hypothetically, profitable for a company to run a clinical trials portfolio of chemically inert compounds. While the current cancer drug pipeline is certainly superior to inert drugs, we must rethink market incentives to encourage transformational drug development.

Original language	English (US)
Pages (from-to)	399-400
Number of pages	2
Journal	Nature Reviews Clinical Oncology
Volume	15
Issue number	7
DOIs	https://doi.org/10.1038/s41571-018-0030-2
State	Published - Jul 1 2018

ASJC Scopus subject areas

Oncology

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10.1038/s41571-018-0030-2

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abstract = "Drug regulators' acceptance of any statistically significant improvement shown in a single randomized trial and lofty drug prices has created a situation where it is now, hypothetically, profitable for a company to run a clinical trials portfolio of chemically inert compounds. While the current cancer drug pipeline is certainly superior to inert drugs, we must rethink market incentives to encourage transformational drug development.",

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Low-value approvals and high prices might incentivize ineffective drug development

Abstract

ASJC Scopus subject areas

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