Low intracellular iron increases the stability of Matriptase-2

Ningning Zhao, Christopher P. Nizzi, Sheila A. Anderson, Jiaohong Wang, Akiko Ueno, Hidekazu Tsukamoto, Richard S. Eisenstein, Caroline A. Enns, An Sheng Zhang

Research output: Contribution to journalArticle

31 Scopus citations


Background: Matriptase-2 (MT2) is essential for iron homeostasis. The mechanism for its regulation is controversial. Results: The cytoplasmic domain of MT2 is necessary for its stabilization by iron depletion. MT2 expression is not regulated at either the transcriptional mRNA or translational level by iron. Conclusion: Depletion of cellular iron stabilizes MT2. Significance: Low iron levels in hepatocytes stabilize MT2 to suppress hepcidin expression.

Original languageEnglish (US)
Pages (from-to)4432-4446
Number of pages15
JournalJournal of Biological Chemistry
Issue number7
StatePublished - Feb 13 2015

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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    Zhao, N., Nizzi, C. P., Anderson, S. A., Wang, J., Ueno, A., Tsukamoto, H., Eisenstein, R. S., Enns, C. A., & Zhang, A. S. (2015). Low intracellular iron increases the stability of Matriptase-2. Journal of Biological Chemistry, 290(7), 4432-4446. https://doi.org/10.1074/jbc.M114.611913