Low intracellular iron increases the stability of Matriptase-2

Ningning Zhao, Christopher P. Nizzi, Sheila A. Anderson, Jiaohong Wang, Akiko Ueno, Hidekazu Tsukamoto, Richard S. Eisenstein, Caroline Enns, An-Sheng Zhang

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Background: Matriptase-2 (MT2) is essential for iron homeostasis. The mechanism for its regulation is controversial. Results: The cytoplasmic domain of MT2 is necessary for its stabilization by iron depletion. MT2 expression is not regulated at either the transcriptional mRNA or translational level by iron. Conclusion: Depletion of cellular iron stabilizes MT2. Significance: Low iron levels in hepatocytes stabilize MT2 to suppress hepcidin expression.

Original languageEnglish (US)
Pages (from-to)4432-4446
Number of pages15
JournalJournal of Biological Chemistry
Volume290
Issue number7
DOIs
StatePublished - Feb 13 2015

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Iron
Hepcidins
Hepatocytes
Homeostasis
Stabilization
matriptase 2
Messenger RNA

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Molecular Biology

Cite this

Zhao, N., Nizzi, C. P., Anderson, S. A., Wang, J., Ueno, A., Tsukamoto, H., ... Zhang, A-S. (2015). Low intracellular iron increases the stability of Matriptase-2. Journal of Biological Chemistry, 290(7), 4432-4446. https://doi.org/10.1074/jbc.M114.611913

Low intracellular iron increases the stability of Matriptase-2. / Zhao, Ningning; Nizzi, Christopher P.; Anderson, Sheila A.; Wang, Jiaohong; Ueno, Akiko; Tsukamoto, Hidekazu; Eisenstein, Richard S.; Enns, Caroline; Zhang, An-Sheng.

In: Journal of Biological Chemistry, Vol. 290, No. 7, 13.02.2015, p. 4432-4446.

Research output: Contribution to journalArticle

Zhao, N, Nizzi, CP, Anderson, SA, Wang, J, Ueno, A, Tsukamoto, H, Eisenstein, RS, Enns, C & Zhang, A-S 2015, 'Low intracellular iron increases the stability of Matriptase-2', Journal of Biological Chemistry, vol. 290, no. 7, pp. 4432-4446. https://doi.org/10.1074/jbc.M114.611913
Zhao N, Nizzi CP, Anderson SA, Wang J, Ueno A, Tsukamoto H et al. Low intracellular iron increases the stability of Matriptase-2. Journal of Biological Chemistry. 2015 Feb 13;290(7):4432-4446. https://doi.org/10.1074/jbc.M114.611913
Zhao, Ningning ; Nizzi, Christopher P. ; Anderson, Sheila A. ; Wang, Jiaohong ; Ueno, Akiko ; Tsukamoto, Hidekazu ; Eisenstein, Richard S. ; Enns, Caroline ; Zhang, An-Sheng. / Low intracellular iron increases the stability of Matriptase-2. In: Journal of Biological Chemistry. 2015 ; Vol. 290, No. 7. pp. 4432-4446.
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