Loss of pons-to-hypothalamic white matter tracks in brainstem obesity

Jonathan Purnell, D. L. Lahna, Mary Samuels, William Rooney, W. F. Hoffman

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Hyperphagia and obesity have been reported following damage to the hypothalamus in humans. Other brain sites are also postulated to be involved in the control of food intake and body weight regulation, such as the amygdala and brainstem. The brainstem, however, is thought to primarily integrate short-term meal-related signals but not affect long-term alterations in body weight, which is controlled by higher centers. The objective of this study was to identify structural pathways damaged in a patient with a brainstem cavernoma who experienced sudden onset of hyperphagia and >50 kg weight gain in

Original languageEnglish (US)
Pages (from-to)1573-1577
Number of pages5
JournalInternational Journal of Obesity
Volume38
Issue number12
DOIs
StatePublished - Dec 11 2014

Fingerprint

Pons
Brain Stem
Hyperphagia
Obesity
Body Weight
Amygdala
Hypothalamus
Weight Gain
Meals
Eating
Brain
White Matter

Keywords

  • bariatric surgery
  • brainstem
  • diffusion tensor imaging
  • magnetic resonance imaging

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics
  • Endocrinology, Diabetes and Metabolism

Cite this

Loss of pons-to-hypothalamic white matter tracks in brainstem obesity. / Purnell, Jonathan; Lahna, D. L.; Samuels, Mary; Rooney, William; Hoffman, W. F.

In: International Journal of Obesity, Vol. 38, No. 12, 11.12.2014, p. 1573-1577.

Research output: Contribution to journalArticle

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