Loss of leishmanin skin test antigen sensitivity and potency in a longitudinal study of visceral Leishmaniasis in Bangladesh

Caryn Bern, Josef Amann, Rashidul Haque, Rajib Chowdhury, Mustakim Ali, Katie M. Kurkjian, Louise Vaz, Yukiko Wagatsuma, Robert F. Breiman, W. Evan Secor, James H. Maguire

Research output: Contribution to journalArticle

25 Scopus citations

Abstract

Annual leishmanin skin test (LST) surveys were conducted in a visceral leishmaniasis-endemic Bangladeshi community from 2002 through 2004, using Leishmania infantum antigen from the same manufacturer and batch. In 2002, 530 (35%) of 1,532 had positive LST results; the prevalence increased with increasing age. The LST result was positive in 24 (51%) of 47, 18 (72%) of 25, and 11 (85%) of 13 kala-azar patients treated in the previous 1-11, 12-23, and 24-35 months. A positive LST result in 2002 was associated with protection against subsequent kala-azar (P < 0.0001). In 2003-2004, decreased antigen sensitivity was observed. Among 686 participants, 34% were LST-positive in 2002, 29% in 2003, and 19% in 2004. Of 63 cured kala-azar patients, 70% were positive in 2002, 53% in 2003, and only 30% in 2004. Among 171 participants tested with both antigens, L. infantum study antigen sensitivity was 70% compared with L. amazonensis antigen. Our data underscore the need for better production, standardization, and documentation of sensitivity, potency, and stability of leishmanin antigens.

Original languageEnglish (US)
Pages (from-to)744-748
Number of pages5
JournalAmerican Journal of Tropical Medicine and Hygiene
Volume75
Issue number4
StatePublished - Dec 1 2006

ASJC Scopus subject areas

  • Parasitology
  • Virology
  • Infectious Diseases

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    Bern, C., Amann, J., Haque, R., Chowdhury, R., Ali, M., Kurkjian, K. M., Vaz, L., Wagatsuma, Y., Breiman, R. F., Secor, W. E., & Maguire, J. H. (2006). Loss of leishmanin skin test antigen sensitivity and potency in a longitudinal study of visceral Leishmaniasis in Bangladesh. American Journal of Tropical Medicine and Hygiene, 75(4), 744-748.