Longterm effectiveness of herpes zoster vaccine among patients with autoimmune and inflammatory diseases

Huifeng Yun, Fenglong Xie, John W. Baddley, Kevin Winthrop, Kenneth G. Saag, Jeffrey R. Curtis

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Objective. The protection duration of herpes zoster (HZ) vaccination is unclear among patients with autoimmune (AI) diseases. Methods. Using 2006-2013 Medicare data, HZ vaccinated patients with AI were matched 1:2 to unvaccinated HZ. Incidence rates (IR) and adjusted risk ratios over time were calculated using Poisson regression. Results. Of 59,627 vaccinated patients, crude IR increased from 0.75/100 person-years during the first year post-vaccination to 1.25 during the seventh year. Vaccinated patients had a significantly lower risk of HZ compared with the unvaccinated through 5 years. Conclusion. HZ vaccination was significantly protective only for about 5 years among patients with AI.

Original languageEnglish (US)
Pages (from-to)1083-1087
Number of pages5
JournalJournal of Rheumatology
Volume44
Issue number7
DOIs
StatePublished - Jul 1 2017

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Herpes Zoster Vaccine
Herpes Zoster
Autoimmune Diseases
Vaccination
Incidence
Medicare
Odds Ratio

Keywords

  • Autoimmune diseases
  • Herpes zoster
  • Infection
  • Vaccination

ASJC Scopus subject areas

  • Immunology and Allergy
  • Rheumatology
  • Immunology

Cite this

Longterm effectiveness of herpes zoster vaccine among patients with autoimmune and inflammatory diseases. / Yun, Huifeng; Xie, Fenglong; Baddley, John W.; Winthrop, Kevin; Saag, Kenneth G.; Curtis, Jeffrey R.

In: Journal of Rheumatology, Vol. 44, No. 7, 01.07.2017, p. 1083-1087.

Research output: Contribution to journalArticle

Yun, Huifeng ; Xie, Fenglong ; Baddley, John W. ; Winthrop, Kevin ; Saag, Kenneth G. ; Curtis, Jeffrey R. / Longterm effectiveness of herpes zoster vaccine among patients with autoimmune and inflammatory diseases. In: Journal of Rheumatology. 2017 ; Vol. 44, No. 7. pp. 1083-1087.
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