Abstract
Exposure to methamphetamine during brain development impairs cognition in children and adult rodents. In mice, these impairments are greater in females than males. Adult female, but not male, mice show impairments in novel location recognition following methamphetamine exposure during brain development. In contrast to adulthood, little is known about the potential effects of methamphetamine exposure on cognition in adolescent mice. As adolescence is an important time of development and is relatively understudied, the aim of the current study was to examine potential long-term effects of neonatal methamphetamine exposure on behavior and cognition during adolescence. Male and female mice were exposed to methamphetamine (5. mg/kg) or saline once a day from postnatal days 11 to 20, the period of rodent hippocampal development. Behavioral and cognitive function was assessed during adolescence beginning on postnatal day 30. During the injection period, methamphetamine-exposed mice gained less weight on average compared to saline-exposed mice. In both male and female mice, methamphetamine exposure significantly impaired novel object recognition and there was a trend toward impaired novel location recognition. Anxiety-like behavior, sensorimotor gating, and contextual and cued fear conditioning were not affected by methamphetamine exposure. Thus, neonatal methamphetamine exposure affects cognition in adolescence and unlike in adulthood equally affects male and female mice.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 159-164 |
| Number of pages | 6 |
| Journal | Behavioural Brain Research |
| Volume | 219 |
| Issue number | 1 |
| DOIs | |
| State | Published - May 16 2011 |
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Keywords
- Adolescence
- Cognition
- Hippocampus
- Methamphetamine
- Postnatal
ASJC Scopus subject areas
- Behavioral Neuroscience
Cite this
Long-term effects of neonatal methamphetamine exposure on cognitive function in adolescent mice. / Siegel, Jessica A.; Park, Byung; Raber, Jacob.
In: Behavioural Brain Research, Vol. 219, No. 1, 16.05.2011, p. 159-164.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Long-term effects of neonatal methamphetamine exposure on cognitive function in adolescent mice
AU - Siegel, Jessica A.
AU - Park, Byung
AU - Raber, Jacob
PY - 2011/5/16
Y1 - 2011/5/16
N2 - Exposure to methamphetamine during brain development impairs cognition in children and adult rodents. In mice, these impairments are greater in females than males. Adult female, but not male, mice show impairments in novel location recognition following methamphetamine exposure during brain development. In contrast to adulthood, little is known about the potential effects of methamphetamine exposure on cognition in adolescent mice. As adolescence is an important time of development and is relatively understudied, the aim of the current study was to examine potential long-term effects of neonatal methamphetamine exposure on behavior and cognition during adolescence. Male and female mice were exposed to methamphetamine (5. mg/kg) or saline once a day from postnatal days 11 to 20, the period of rodent hippocampal development. Behavioral and cognitive function was assessed during adolescence beginning on postnatal day 30. During the injection period, methamphetamine-exposed mice gained less weight on average compared to saline-exposed mice. In both male and female mice, methamphetamine exposure significantly impaired novel object recognition and there was a trend toward impaired novel location recognition. Anxiety-like behavior, sensorimotor gating, and contextual and cued fear conditioning were not affected by methamphetamine exposure. Thus, neonatal methamphetamine exposure affects cognition in adolescence and unlike in adulthood equally affects male and female mice.
AB - Exposure to methamphetamine during brain development impairs cognition in children and adult rodents. In mice, these impairments are greater in females than males. Adult female, but not male, mice show impairments in novel location recognition following methamphetamine exposure during brain development. In contrast to adulthood, little is known about the potential effects of methamphetamine exposure on cognition in adolescent mice. As adolescence is an important time of development and is relatively understudied, the aim of the current study was to examine potential long-term effects of neonatal methamphetamine exposure on behavior and cognition during adolescence. Male and female mice were exposed to methamphetamine (5. mg/kg) or saline once a day from postnatal days 11 to 20, the period of rodent hippocampal development. Behavioral and cognitive function was assessed during adolescence beginning on postnatal day 30. During the injection period, methamphetamine-exposed mice gained less weight on average compared to saline-exposed mice. In both male and female mice, methamphetamine exposure significantly impaired novel object recognition and there was a trend toward impaired novel location recognition. Anxiety-like behavior, sensorimotor gating, and contextual and cued fear conditioning were not affected by methamphetamine exposure. Thus, neonatal methamphetamine exposure affects cognition in adolescence and unlike in adulthood equally affects male and female mice.
KW - Adolescence
KW - Cognition
KW - Hippocampus
KW - Methamphetamine
KW - Postnatal
UR - http://www.scopus.com/inward/record.url?scp=79251565228&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=79251565228&partnerID=8YFLogxK
U2 - 10.1016/j.bbr.2011.01.015
DO - 10.1016/j.bbr.2011.01.015
M3 - Article
C2 - 21238498
AN - SCOPUS:79251565228
VL - 219
SP - 159
EP - 164
JO - Behavioural Brain Research
JF - Behavioural Brain Research
SN - 0166-4328
IS - 1
ER -