Abstract
Objectives: The goal of this study was to test the effects of long-chain omega-3 fatty acid supplementation on omega-3 levels, depressive symptoms, and other psychosocial factors, as well as other chronic heart failure (CHF)-related functional measures. Background: Patients with CHF and depression had low blood omega-3 concentrations that were associated with an elevated risk of mortality. Methods: This study was a randomized, double-blind, placebo-controlled pilot clinical trial using a 400/200 eicosapentaenoic acid (EPA)/docosahexaenoic acid (DHA) fish oil at 2 g and an almost pure EPA at 2 g, compared with a matched placebo, daily for 12 weeks for patients with CHF and major depressive disorder. Statistical analyses included the intention-to-treat population and “completers” (defined as participants consuming ≥70% of the capsules and completing the final endpoint evaluation between 10 and 14 weeks). Results: A total of 108 patients with CHF and major depressive disorder and a score ≥18 on the Hamilton Depression Scale who were randomized at 1:1:1 to the 3 interventions at 3 enrolling centers from June 12, 2014, to May 19, 2016; 80 (74.1%) qualified as completers. Intention-to-treat analyses revealed that the levels of all omega-3 variables were significantly elevated in the omega-3 groups, whereas the placebo group showed little change; there were no between-group differences with overall depression measurements. Per-protocol exploratory analyses showed that scores on the social functioning measurement of the 36-item Short Form Health Survey improved notably in the 400/200 EPA/DHA (p = 0.040) and EPA (p = 0.10) groups compared with the placebo group. Spearman correlation analysis indicated that increased omega-3 indices were associated with improved cognitive depressive symptoms. Conclusions: Omega-3 supplementation resulted in significant increases in omega-3 levels in red blood cell counts, corresponding to a particular compound of omega-3. Changes in cognitive depressive symptoms and social function were in favor of the omega-3 supplementation. Further studies with larger sample sizes are necessary to confirm the benefits of omega-3 supplementation on modifying psychosocial factors for patients with CHF. (Omega-3 Supplementation for Co-Morbid Depression and Heart Failure Treatment [OCEAN]; NCT02057406)
| Original language | English (US) |
|---|---|
| Pages (from-to) | 833-843 |
| Number of pages | 11 |
| Journal | JACC: Heart Failure |
| Volume | 6 |
| Issue number | 10 |
| DOIs | |
| State | Published - Oct 1 2018 |
| Externally published | Yes |
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Keywords
- congestive heart failure
- long-chain omega-3 fatty acids
- major depressive disorder
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine
Cite this
Long-Chain Omega-3 Fatty Acid Supplements in Depressed Heart Failure Patients : Results of the OCEAN Trial. / Jiang, Wei; Whellan, David J.; Adams, Kirkwood F.; Babyak, Michael A.; Boyle, Stephen H.; Wilson, Jennifer L.; Patel, Chetan B.; Rogers, Joseph G.; Harris, William; O'Connor, Christopher M.
In: JACC: Heart Failure, Vol. 6, No. 10, 01.10.2018, p. 833-843.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Long-Chain Omega-3 Fatty Acid Supplements in Depressed Heart Failure Patients
T2 - Results of the OCEAN Trial
AU - Jiang, Wei
AU - Whellan, David J.
AU - Adams, Kirkwood F.
AU - Babyak, Michael A.
AU - Boyle, Stephen H.
AU - Wilson, Jennifer L.
AU - Patel, Chetan B.
AU - Rogers, Joseph G.
AU - Harris, William
AU - O'Connor, Christopher M.
PY - 2018/10/1
Y1 - 2018/10/1
N2 - Objectives: The goal of this study was to test the effects of long-chain omega-3 fatty acid supplementation on omega-3 levels, depressive symptoms, and other psychosocial factors, as well as other chronic heart failure (CHF)-related functional measures. Background: Patients with CHF and depression had low blood omega-3 concentrations that were associated with an elevated risk of mortality. Methods: This study was a randomized, double-blind, placebo-controlled pilot clinical trial using a 400/200 eicosapentaenoic acid (EPA)/docosahexaenoic acid (DHA) fish oil at 2 g and an almost pure EPA at 2 g, compared with a matched placebo, daily for 12 weeks for patients with CHF and major depressive disorder. Statistical analyses included the intention-to-treat population and “completers” (defined as participants consuming ≥70% of the capsules and completing the final endpoint evaluation between 10 and 14 weeks). Results: A total of 108 patients with CHF and major depressive disorder and a score ≥18 on the Hamilton Depression Scale who were randomized at 1:1:1 to the 3 interventions at 3 enrolling centers from June 12, 2014, to May 19, 2016; 80 (74.1%) qualified as completers. Intention-to-treat analyses revealed that the levels of all omega-3 variables were significantly elevated in the omega-3 groups, whereas the placebo group showed little change; there were no between-group differences with overall depression measurements. Per-protocol exploratory analyses showed that scores on the social functioning measurement of the 36-item Short Form Health Survey improved notably in the 400/200 EPA/DHA (p = 0.040) and EPA (p = 0.10) groups compared with the placebo group. Spearman correlation analysis indicated that increased omega-3 indices were associated with improved cognitive depressive symptoms. Conclusions: Omega-3 supplementation resulted in significant increases in omega-3 levels in red blood cell counts, corresponding to a particular compound of omega-3. Changes in cognitive depressive symptoms and social function were in favor of the omega-3 supplementation. Further studies with larger sample sizes are necessary to confirm the benefits of omega-3 supplementation on modifying psychosocial factors for patients with CHF. (Omega-3 Supplementation for Co-Morbid Depression and Heart Failure Treatment [OCEAN]; NCT02057406)
AB - Objectives: The goal of this study was to test the effects of long-chain omega-3 fatty acid supplementation on omega-3 levels, depressive symptoms, and other psychosocial factors, as well as other chronic heart failure (CHF)-related functional measures. Background: Patients with CHF and depression had low blood omega-3 concentrations that were associated with an elevated risk of mortality. Methods: This study was a randomized, double-blind, placebo-controlled pilot clinical trial using a 400/200 eicosapentaenoic acid (EPA)/docosahexaenoic acid (DHA) fish oil at 2 g and an almost pure EPA at 2 g, compared with a matched placebo, daily for 12 weeks for patients with CHF and major depressive disorder. Statistical analyses included the intention-to-treat population and “completers” (defined as participants consuming ≥70% of the capsules and completing the final endpoint evaluation between 10 and 14 weeks). Results: A total of 108 patients with CHF and major depressive disorder and a score ≥18 on the Hamilton Depression Scale who were randomized at 1:1:1 to the 3 interventions at 3 enrolling centers from June 12, 2014, to May 19, 2016; 80 (74.1%) qualified as completers. Intention-to-treat analyses revealed that the levels of all omega-3 variables were significantly elevated in the omega-3 groups, whereas the placebo group showed little change; there were no between-group differences with overall depression measurements. Per-protocol exploratory analyses showed that scores on the social functioning measurement of the 36-item Short Form Health Survey improved notably in the 400/200 EPA/DHA (p = 0.040) and EPA (p = 0.10) groups compared with the placebo group. Spearman correlation analysis indicated that increased omega-3 indices were associated with improved cognitive depressive symptoms. Conclusions: Omega-3 supplementation resulted in significant increases in omega-3 levels in red blood cell counts, corresponding to a particular compound of omega-3. Changes in cognitive depressive symptoms and social function were in favor of the omega-3 supplementation. Further studies with larger sample sizes are necessary to confirm the benefits of omega-3 supplementation on modifying psychosocial factors for patients with CHF. (Omega-3 Supplementation for Co-Morbid Depression and Heart Failure Treatment [OCEAN]; NCT02057406)
KW - congestive heart failure
KW - long-chain omega-3 fatty acids
KW - major depressive disorder
UR - http://www.scopus.com/inward/record.url?scp=85053370920&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85053370920&partnerID=8YFLogxK
U2 - 10.1016/j.jchf.2018.03.011
DO - 10.1016/j.jchf.2018.03.011
M3 - Article
AN - SCOPUS:85053370920
VL - 6
SP - 833
EP - 843
JO - JACC: Heart Failure
JF - JACC: Heart Failure
SN - 2213-1779
IS - 10
ER -