Locomotor activity predicts acquisition of self-administration behavior but not cocaine intake

Jennifer M. Mitchell, Christopher Cunningham, Gregory Mark

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

The current study investigates locomotor activity in a novel environment and correlates these activity levels with cocaine self-administration in rats that were either trained or untrained on a lever-pressing task prior to cocaine self-administration. The authors report that it is the rate of learning the lever-pressing task, not cocaine self-administration, that correlates with locomotor activity. The results suggest that a correlation between locomotor activity and cocaine self-administration is secondary to a link between locomotor activity and rate of learning to lever press for a reward. The authors conclude that locomotor activity is not necessarily an indicator of propensity to self-administer cocaine and demonstrate that environmental novelty and rate of learning an operant task are important considerations when designing experiments on drug-seeking behaviors.

Original languageEnglish (US)
Pages (from-to)464-472
Number of pages9
JournalBehavioral Neuroscience
Volume119
Issue number2
DOIs
StatePublished - Apr 2005

Fingerprint

Self Administration
Locomotion
Cocaine
Learning
Drug-Seeking Behavior
Reward

Keywords

  • Addiction
  • Cocaine
  • Learning
  • Locomotion
  • Self-administration

ASJC Scopus subject areas

  • Behavioral Neuroscience
  • Clinical Psychology

Cite this

Locomotor activity predicts acquisition of self-administration behavior but not cocaine intake. / Mitchell, Jennifer M.; Cunningham, Christopher; Mark, Gregory.

In: Behavioral Neuroscience, Vol. 119, No. 2, 04.2005, p. 464-472.

Research output: Contribution to journalArticle

@article{fec5c7a1c09d4989b0cf767a5c670435,
title = "Locomotor activity predicts acquisition of self-administration behavior but not cocaine intake",
abstract = "The current study investigates locomotor activity in a novel environment and correlates these activity levels with cocaine self-administration in rats that were either trained or untrained on a lever-pressing task prior to cocaine self-administration. The authors report that it is the rate of learning the lever-pressing task, not cocaine self-administration, that correlates with locomotor activity. The results suggest that a correlation between locomotor activity and cocaine self-administration is secondary to a link between locomotor activity and rate of learning to lever press for a reward. The authors conclude that locomotor activity is not necessarily an indicator of propensity to self-administer cocaine and demonstrate that environmental novelty and rate of learning an operant task are important considerations when designing experiments on drug-seeking behaviors.",
keywords = "Addiction, Cocaine, Learning, Locomotion, Self-administration",
author = "Mitchell, {Jennifer M.} and Christopher Cunningham and Gregory Mark",
year = "2005",
month = "4",
doi = "10.1037/0735-7044.119.2.464",
language = "English (US)",
volume = "119",
pages = "464--472",
journal = "Behavioral Neuroscience",
issn = "0735-7044",
publisher = "American Psychological Association Inc.",
number = "2",

}

TY - JOUR

T1 - Locomotor activity predicts acquisition of self-administration behavior but not cocaine intake

AU - Mitchell, Jennifer M.

AU - Cunningham, Christopher

AU - Mark, Gregory

PY - 2005/4

Y1 - 2005/4

N2 - The current study investigates locomotor activity in a novel environment and correlates these activity levels with cocaine self-administration in rats that were either trained or untrained on a lever-pressing task prior to cocaine self-administration. The authors report that it is the rate of learning the lever-pressing task, not cocaine self-administration, that correlates with locomotor activity. The results suggest that a correlation between locomotor activity and cocaine self-administration is secondary to a link between locomotor activity and rate of learning to lever press for a reward. The authors conclude that locomotor activity is not necessarily an indicator of propensity to self-administer cocaine and demonstrate that environmental novelty and rate of learning an operant task are important considerations when designing experiments on drug-seeking behaviors.

AB - The current study investigates locomotor activity in a novel environment and correlates these activity levels with cocaine self-administration in rats that were either trained or untrained on a lever-pressing task prior to cocaine self-administration. The authors report that it is the rate of learning the lever-pressing task, not cocaine self-administration, that correlates with locomotor activity. The results suggest that a correlation between locomotor activity and cocaine self-administration is secondary to a link between locomotor activity and rate of learning to lever press for a reward. The authors conclude that locomotor activity is not necessarily an indicator of propensity to self-administer cocaine and demonstrate that environmental novelty and rate of learning an operant task are important considerations when designing experiments on drug-seeking behaviors.

KW - Addiction

KW - Cocaine

KW - Learning

KW - Locomotion

KW - Self-administration

UR - http://www.scopus.com/inward/record.url?scp=17444388490&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=17444388490&partnerID=8YFLogxK

U2 - 10.1037/0735-7044.119.2.464

DO - 10.1037/0735-7044.119.2.464

M3 - Article

VL - 119

SP - 464

EP - 472

JO - Behavioral Neuroscience

JF - Behavioral Neuroscience

SN - 0735-7044

IS - 2

ER -