Localization of Xenopus Vg1 mRNA by Vera protein and the endoplasmic reticulum

James O. Deshler, Martin I. Highett, Bruce Schnapp

Research output: Contribution to journalArticle

215 Citations (Scopus)

Abstract

In many organisms, pattern formation in the embryo develops from the polarized distributions of messenger RNAs (mRNAs) in the egg. In Xenopus, the mRNA encoding Vg1, a growth factor involved in mesoderm induction, is localized to the vegetal cortex of oocytes. A protein named Vera was shown to be involved in Vg1 mRNA localization. Vera cofractionates with endoplasmic reticulum (ER) membranes, and endogenous Vg1 mRNA is associated with a subcompartment of the ER. Vera may promote mRNA localization in Xenopus oocytes by mediating an interaction between the Vg1 3' untranslated region and the ER subcompartment.

Original languageEnglish (US)
Pages (from-to)1128-1131
Number of pages4
JournalScience
Volume276
Issue number5315
DOIs
StatePublished - May 16 1997
Externally publishedYes

Fingerprint

Xenopus
Endoplasmic Reticulum
Messenger RNA
Proteins
Oocytes
3' Untranslated Regions
Mesoderm
Ovum
Intercellular Signaling Peptides and Proteins
Embryonic Structures
Membranes

ASJC Scopus subject areas

  • General

Cite this

Localization of Xenopus Vg1 mRNA by Vera protein and the endoplasmic reticulum. / Deshler, James O.; Highett, Martin I.; Schnapp, Bruce.

In: Science, Vol. 276, No. 5315, 16.05.1997, p. 1128-1131.

Research output: Contribution to journalArticle

Deshler, James O. ; Highett, Martin I. ; Schnapp, Bruce. / Localization of Xenopus Vg1 mRNA by Vera protein and the endoplasmic reticulum. In: Science. 1997 ; Vol. 276, No. 5315. pp. 1128-1131.
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