Localization of voltage-sensitive L-type calcium channels in the chicken retina

Sally I. Firth, Ian G. Morgan, Meeuwis K. Boelen, Catherine W. Morgans

Research output: Contribution to journalArticlepeer-review

35 Scopus citations

Abstract

L-type calcium channels have been associated with synaptic transmission in the retina, and are a potential site for modulation of the release of neurotransmitters. The present study documents the immunohistochemical localization of neuronal α 1 subunits of L-type calcium channels in chicken retina, using antibodies to the α 1 c, α 1 d and α 1 f subunits of L-type calcium channels. The α 1 c-like subunits were localized to Müller cells, with predominantly radial processes, and a prominent band of horizontal processes in the outer plexiform layer. The antibody to α 1 d subunits labelled most, if not all, cell bodies. The antibody to a human α 1 f subunit strongly labelled photoreceptor terminals. Fainter immunoreactivity was detected in the inner segments of the photoreceptors, a subset of amacrine cells, two bands of labelling in the inner plexiform layer and many ganglion cells. The differential cellular distributions of these α 1 -subunits suggests subtle functional differences in their roles at different cellular locations.

Original languageEnglish (US)
Pages (from-to)183-187
Number of pages5
JournalClinical and Experimental Ophthalmology
Volume29
Issue number3
DOIs
StatePublished - 2001
Externally publishedYes

Keywords

  • Calcium channels
  • Chicken
  • Immunohistochemistry
  • Müller cells
  • Retina
  • α 1 subunits

ASJC Scopus subject areas

  • Ophthalmology

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