Localization of voltage-sensitive L-type calcium channels in the chicken retina

Sally I. Firth, Ian G. Morgan, Meeuwis K. Boelen, Catherine W. Morgans

    Research output: Contribution to journalArticle

    35 Scopus citations

    Abstract

    L-type calcium channels have been associated with synaptic transmission in the retina, and are a potential site for modulation of the release of neurotransmitters. The present study documents the immunohistochemical localization of neuronal α 1 subunits of L-type calcium channels in chicken retina, using antibodies to the α 1 c, α 1 d and α 1 f subunits of L-type calcium channels. The α 1 c-like subunits were localized to Müller cells, with predominantly radial processes, and a prominent band of horizontal processes in the outer plexiform layer. The antibody to α 1 d subunits labelled most, if not all, cell bodies. The antibody to a human α 1 f subunit strongly labelled photoreceptor terminals. Fainter immunoreactivity was detected in the inner segments of the photoreceptors, a subset of amacrine cells, two bands of labelling in the inner plexiform layer and many ganglion cells. The differential cellular distributions of these α 1 -subunits suggests subtle functional differences in their roles at different cellular locations.

    Original languageEnglish (US)
    Pages (from-to)183-187
    Number of pages5
    JournalClinical and Experimental Ophthalmology
    Volume29
    Issue number3
    DOIs
    StatePublished - Jul 18 2001

    Keywords

    • Calcium channels
    • Chicken
    • Immunohistochemistry
    • Müller cells
    • Retina
    • α 1 subunits

    ASJC Scopus subject areas

    • Ophthalmology

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