Localization of Fibrillin-I in the Human Term Placenta

Sig Linda Jacobson, Dwight Kimberly, Kent Thornburg, Cheryl Maslen

    Research output: Contribution to journalArticle

    7 Scopus citations

    Abstract

    Objective: We determined the level of message for fibrillin-1, a single-stranded glycoprotein found in the elastic micropfibrils of the extracellular matrix, in human placenta compared with other adult human tissues and localized the protein int he term human placenta. Methods: Northern blot analysis using a cDNA specific for fibrillin-1 was used to compare message levels in several adult human tissues and placenta. Immunohistochemical staining, using a monoclonal antibody to human fibrillin-1, was used to visualize the sitz of fibrillin-1 in term human placenta. Results: Larger amounts of message for fibrillin-1 were present in placenta than in any of the other tissues tested. Staining for fibrillin-1 was present in the villous stroma but not in the basement membranes, trophoblast cells, or in blood vessels of stem, mature intermediate, or terminal villi. Conclusions: Fibrillin-1 is distributed extensively in the villous stroma of the term human placenta and may contribute elastic properties to the placenta and basal plate required for an active uterus.

    Original languageEnglish (US)
    Pages (from-to)686-690
    Number of pages5
    JournalJournal of the Society for Gynecologic Investigation
    Volume2
    Issue number5
    DOIs
    StatePublished - Sep 1995

    Keywords

    • Placenta
    • extracellular matix
    • fibrillin-1
    • immunohistochemistry
    • microfibril

    ASJC Scopus subject areas

    • Obstetrics and Gynecology

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