Localisation of interleukin 8 in the synovial membrane, cartilagepannus junction and chondrocytes in rheumatoid arthritis

B. Deleuran, P. Lemche, M. Kristensen, Cong-Qiu Chu, M. Field, J. Jensen, K. Matsushima, K. Stengaard-Pedersen

Research output: Contribution to journalArticle

73 Citations (Scopus)

Abstract

Interleukin-8 (IL-8) may play an important role in the development of synovitis in rheumatoid arthritis (RA), in that it is a powerful chemoattractant for neutrophils and T cells. The aim of this study was to examine the distribution of IL-8 in the synovial membrane and cartilage, from RA, osteoarthritis (OA) and normal joints. By immunohistochemical techniques, IL-8 was shown to be present in the lining layer cells in RA (87% and in OA (62% By contrast, only a few of the normal synovial lining layer cells (14% contained IL-8. Deeper in the membrane the number of IL-8 positive cells decreased. Only vessels were highly positive for IL-8. At the RA cartilage-pannus junction 26% of the cells contained IL-8, whereas at the OA cartilage-pannus junction 8% of the cells were IL-8 positive (P <0.05). Chondrocytes present in joint surface cartilage stained positive for IL-8 in an average of 20% of the cells of both RA and OA. These results provide histological evidence that IL-8 is present in the arthritic synovial tissue and cartilage, and is distributed in a manner that may form a chemotactic gradient, which favours localisation of neutrophils to the joint lumen.

Original languageEnglish (US)
Pages (from-to)2-7
Number of pages6
JournalScandinavian Journal of Rheumatology
Volume23
Issue number1
DOIs
StatePublished - 1994
Externally publishedYes

Fingerprint

Synovial Membrane
Chondrocytes
Interleukin-8
Rheumatoid Arthritis
Cartilage
Osteoarthritis
Intercellular Junctions
Joints
Neutrophils
Synovitis
Chemotactic Factors
Arthritis
T-Lymphocytes
Membranes

Keywords

  • Cartilage-pannus junction
  • Chondrocytes
  • Interleukin 8
  • Rheumatoid arthritis
  • Synovial membrane

ASJC Scopus subject areas

  • Rheumatology
  • Immunology
  • Immunology and Allergy

Cite this

Localisation of interleukin 8 in the synovial membrane, cartilagepannus junction and chondrocytes in rheumatoid arthritis. / Deleuran, B.; Lemche, P.; Kristensen, M.; Chu, Cong-Qiu; Field, M.; Jensen, J.; Matsushima, K.; Stengaard-Pedersen, K.

In: Scandinavian Journal of Rheumatology, Vol. 23, No. 1, 1994, p. 2-7.

Research output: Contribution to journalArticle

Deleuran, B, Lemche, P, Kristensen, M, Chu, C-Q, Field, M, Jensen, J, Matsushima, K & Stengaard-Pedersen, K 1994, 'Localisation of interleukin 8 in the synovial membrane, cartilagepannus junction and chondrocytes in rheumatoid arthritis', Scandinavian Journal of Rheumatology, vol. 23, no. 1, pp. 2-7. https://doi.org/10.3109/03009749409102126
Deleuran, B. ; Lemche, P. ; Kristensen, M. ; Chu, Cong-Qiu ; Field, M. ; Jensen, J. ; Matsushima, K. ; Stengaard-Pedersen, K. / Localisation of interleukin 8 in the synovial membrane, cartilagepannus junction and chondrocytes in rheumatoid arthritis. In: Scandinavian Journal of Rheumatology. 1994 ; Vol. 23, No. 1. pp. 2-7.
@article{9de25deb5dbb4cd29358dcc1cb07d356,
title = "Localisation of interleukin 8 in the synovial membrane, cartilagepannus junction and chondrocytes in rheumatoid arthritis",
abstract = "Interleukin-8 (IL-8) may play an important role in the development of synovitis in rheumatoid arthritis (RA), in that it is a powerful chemoattractant for neutrophils and T cells. The aim of this study was to examine the distribution of IL-8 in the synovial membrane and cartilage, from RA, osteoarthritis (OA) and normal joints. By immunohistochemical techniques, IL-8 was shown to be present in the lining layer cells in RA (87{\%} and in OA (62{\%} By contrast, only a few of the normal synovial lining layer cells (14{\%} contained IL-8. Deeper in the membrane the number of IL-8 positive cells decreased. Only vessels were highly positive for IL-8. At the RA cartilage-pannus junction 26{\%} of the cells contained IL-8, whereas at the OA cartilage-pannus junction 8{\%} of the cells were IL-8 positive (P <0.05). Chondrocytes present in joint surface cartilage stained positive for IL-8 in an average of 20{\%} of the cells of both RA and OA. These results provide histological evidence that IL-8 is present in the arthritic synovial tissue and cartilage, and is distributed in a manner that may form a chemotactic gradient, which favours localisation of neutrophils to the joint lumen.",
keywords = "Cartilage-pannus junction, Chondrocytes, Interleukin 8, Rheumatoid arthritis, Synovial membrane",
author = "B. Deleuran and P. Lemche and M. Kristensen and Cong-Qiu Chu and M. Field and J. Jensen and K. Matsushima and K. Stengaard-Pedersen",
year = "1994",
doi = "10.3109/03009749409102126",
language = "English (US)",
volume = "23",
pages = "2--7",
journal = "Scandinavian Journal of Rheumatology",
issn = "0300-9742",
publisher = "Informa Healthcare",
number = "1",

}

TY - JOUR

T1 - Localisation of interleukin 8 in the synovial membrane, cartilagepannus junction and chondrocytes in rheumatoid arthritis

AU - Deleuran, B.

AU - Lemche, P.

AU - Kristensen, M.

AU - Chu, Cong-Qiu

AU - Field, M.

AU - Jensen, J.

AU - Matsushima, K.

AU - Stengaard-Pedersen, K.

PY - 1994

Y1 - 1994

N2 - Interleukin-8 (IL-8) may play an important role in the development of synovitis in rheumatoid arthritis (RA), in that it is a powerful chemoattractant for neutrophils and T cells. The aim of this study was to examine the distribution of IL-8 in the synovial membrane and cartilage, from RA, osteoarthritis (OA) and normal joints. By immunohistochemical techniques, IL-8 was shown to be present in the lining layer cells in RA (87% and in OA (62% By contrast, only a few of the normal synovial lining layer cells (14% contained IL-8. Deeper in the membrane the number of IL-8 positive cells decreased. Only vessels were highly positive for IL-8. At the RA cartilage-pannus junction 26% of the cells contained IL-8, whereas at the OA cartilage-pannus junction 8% of the cells were IL-8 positive (P <0.05). Chondrocytes present in joint surface cartilage stained positive for IL-8 in an average of 20% of the cells of both RA and OA. These results provide histological evidence that IL-8 is present in the arthritic synovial tissue and cartilage, and is distributed in a manner that may form a chemotactic gradient, which favours localisation of neutrophils to the joint lumen.

AB - Interleukin-8 (IL-8) may play an important role in the development of synovitis in rheumatoid arthritis (RA), in that it is a powerful chemoattractant for neutrophils and T cells. The aim of this study was to examine the distribution of IL-8 in the synovial membrane and cartilage, from RA, osteoarthritis (OA) and normal joints. By immunohistochemical techniques, IL-8 was shown to be present in the lining layer cells in RA (87% and in OA (62% By contrast, only a few of the normal synovial lining layer cells (14% contained IL-8. Deeper in the membrane the number of IL-8 positive cells decreased. Only vessels were highly positive for IL-8. At the RA cartilage-pannus junction 26% of the cells contained IL-8, whereas at the OA cartilage-pannus junction 8% of the cells were IL-8 positive (P <0.05). Chondrocytes present in joint surface cartilage stained positive for IL-8 in an average of 20% of the cells of both RA and OA. These results provide histological evidence that IL-8 is present in the arthritic synovial tissue and cartilage, and is distributed in a manner that may form a chemotactic gradient, which favours localisation of neutrophils to the joint lumen.

KW - Cartilage-pannus junction

KW - Chondrocytes

KW - Interleukin 8

KW - Rheumatoid arthritis

KW - Synovial membrane

UR - http://www.scopus.com/inward/record.url?scp=0028009807&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028009807&partnerID=8YFLogxK

U2 - 10.3109/03009749409102126

DO - 10.3109/03009749409102126

M3 - Article

C2 - 8108662

AN - SCOPUS:0028009807

VL - 23

SP - 2

EP - 7

JO - Scandinavian Journal of Rheumatology

JF - Scandinavian Journal of Rheumatology

SN - 0300-9742

IS - 1

ER -