Localisation of interleukin 8 in the synovial membrane, cartilagepannus junction and chondrocytes in rheumatoid arthritis

B. Deleuran, P. Lemche, M. Kristensen, C. Q. Chu, M. Field, J. Jensen, K. Matsushima, K. Stengaard-Pedersen

Research output: Contribution to journalArticle

74 Scopus citations

Abstract

Interleukin-8 (IL-8) may play an important role in the development of synovitis in rheumatoid arthritis (RA), in that it is a powerful chemoattractant for neutrophils and T cells. The aim of this study was to examine the distribution of IL-8 in the synovial membrane and cartilage, from RA, osteoarthritis (OA) and normal joints. By immunohistochemical techniques, IL-8 was shown to be present in the lining layer cells in RA (87% and in OA (62% By contrast, only a few of the normal synovial lining layer cells (14% contained IL-8. Deeper in the membrane the number of IL-8 positive cells decreased. Only vessels were highly positive for IL-8. At the RA cartilage-pannus junction 26% of the cells contained IL-8, whereas at the OA cartilage-pannus junction 8% of the cells were IL-8 positive (P < 0.05). Chondrocytes present in joint surface cartilage stained positive for IL-8 in an average of 20% of the cells of both RA and OA. These results provide histological evidence that IL-8 is present in the arthritic synovial tissue and cartilage, and is distributed in a manner that may form a chemotactic gradient, which favours localisation of neutrophils to the joint lumen.

Original languageEnglish (US)
Pages (from-to)2-7
Number of pages6
JournalScandinavian Journal of Rheumatology
Volume23
Issue number1
DOIs
StatePublished - Jan 1 1994

Keywords

  • Cartilage-pannus junction
  • Chondrocytes
  • Interleukin 8
  • Rheumatoid arthritis
  • Synovial membrane

ASJC Scopus subject areas

  • Immunology and Allergy
  • Rheumatology
  • Immunology

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    Deleuran, B., Lemche, P., Kristensen, M., Chu, C. Q., Field, M., Jensen, J., Matsushima, K., & Stengaard-Pedersen, K. (1994). Localisation of interleukin 8 in the synovial membrane, cartilagepannus junction and chondrocytes in rheumatoid arthritis. Scandinavian Journal of Rheumatology, 23(1), 2-7. https://doi.org/10.3109/03009749409102126