Light Chain Podocytopathy Mimicking Recurrent Focal Segmental Glomerulosclerosis

Mazdak Khalighi, M. P. Revelo, J. D. Abraham, F. Shihab, F. Ahmed

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Kidney injury related to paraproteinemia is common and typically occurs after the fourth decade of life in association with an underlying plasma cell dyscrasia or other lymphoproliferative disease. Kidney transplantation in paraprotein-related kidney disease can be successful in conjunction with treatment of the underlying hematopoietic process; however, when hematologic response to therapy is not achieved, recurrent kidney injury is frequently seen. We describe a young male patient who presented at the age of 23 years with end-stage kidney disease thought to be secondary to focal segmental glomerulosclerosis; this patient ultimately received two kidney allografts. He experienced recurrent proteinuria in both kidneys, with a biopsy from his second allograft showing kappa-restricted crystalline light chain podocytopathy, which was identified in both his native and first allograft kidneys upon retrospective review. Recurrent light chain podocytopathy has not been previously reported but poses a diagnostic challenge as it can mimic focal segmental glomerulosclerosis, particularly in young patients in whom paraprotein-related kidney injury is usually not suspected.

Original languageEnglish (US)
Pages (from-to)824-829
Number of pages6
JournalAmerican Journal of Transplantation
Volume17
Issue number3
DOIs
StatePublished - Mar 1 2017
Externally publishedYes

Fingerprint

Focal Segmental Glomerulosclerosis
Kidney
Light
Paraproteins
Allografts
Paraproteinemias
Wounds and Injuries
Kidney Diseases
Proteinuria
Kidney Transplantation
Chronic Kidney Failure
Biopsy
Therapeutics

Keywords

  • biopsy
  • cancer/malignancy/neoplasia: hematogenous/leukemia/lymphoma
  • clinical research/practice
  • kidney (allograft) function/dysfunction
  • kidney transplantation/nephrology
  • pathology/histopathology

ASJC Scopus subject areas

  • Immunology and Allergy
  • Transplantation
  • Pharmacology (medical)

Cite this

Light Chain Podocytopathy Mimicking Recurrent Focal Segmental Glomerulosclerosis. / Khalighi, Mazdak; Revelo, M. P.; Abraham, J. D.; Shihab, F.; Ahmed, F.

In: American Journal of Transplantation, Vol. 17, No. 3, 01.03.2017, p. 824-829.

Research output: Contribution to journalArticle

Khalighi, Mazdak ; Revelo, M. P. ; Abraham, J. D. ; Shihab, F. ; Ahmed, F. / Light Chain Podocytopathy Mimicking Recurrent Focal Segmental Glomerulosclerosis. In: American Journal of Transplantation. 2017 ; Vol. 17, No. 3. pp. 824-829.
@article{ff9bd4563ecc4198992f93dddb53cd1e,
title = "Light Chain Podocytopathy Mimicking Recurrent Focal Segmental Glomerulosclerosis",
abstract = "Kidney injury related to paraproteinemia is common and typically occurs after the fourth decade of life in association with an underlying plasma cell dyscrasia or other lymphoproliferative disease. Kidney transplantation in paraprotein-related kidney disease can be successful in conjunction with treatment of the underlying hematopoietic process; however, when hematologic response to therapy is not achieved, recurrent kidney injury is frequently seen. We describe a young male patient who presented at the age of 23 years with end-stage kidney disease thought to be secondary to focal segmental glomerulosclerosis; this patient ultimately received two kidney allografts. He experienced recurrent proteinuria in both kidneys, with a biopsy from his second allograft showing kappa-restricted crystalline light chain podocytopathy, which was identified in both his native and first allograft kidneys upon retrospective review. Recurrent light chain podocytopathy has not been previously reported but poses a diagnostic challenge as it can mimic focal segmental glomerulosclerosis, particularly in young patients in whom paraprotein-related kidney injury is usually not suspected.",
keywords = "biopsy, cancer/malignancy/neoplasia: hematogenous/leukemia/lymphoma, clinical research/practice, kidney (allograft) function/dysfunction, kidney transplantation/nephrology, pathology/histopathology",
author = "Mazdak Khalighi and Revelo, {M. P.} and Abraham, {J. D.} and F. Shihab and F. Ahmed",
year = "2017",
month = "3",
day = "1",
doi = "10.1111/ajt.14088",
language = "English (US)",
volume = "17",
pages = "824--829",
journal = "American Journal of Transplantation",
issn = "1600-6135",
publisher = "Wiley-Blackwell",
number = "3",

}

TY - JOUR

T1 - Light Chain Podocytopathy Mimicking Recurrent Focal Segmental Glomerulosclerosis

AU - Khalighi, Mazdak

AU - Revelo, M. P.

AU - Abraham, J. D.

AU - Shihab, F.

AU - Ahmed, F.

PY - 2017/3/1

Y1 - 2017/3/1

N2 - Kidney injury related to paraproteinemia is common and typically occurs after the fourth decade of life in association with an underlying plasma cell dyscrasia or other lymphoproliferative disease. Kidney transplantation in paraprotein-related kidney disease can be successful in conjunction with treatment of the underlying hematopoietic process; however, when hematologic response to therapy is not achieved, recurrent kidney injury is frequently seen. We describe a young male patient who presented at the age of 23 years with end-stage kidney disease thought to be secondary to focal segmental glomerulosclerosis; this patient ultimately received two kidney allografts. He experienced recurrent proteinuria in both kidneys, with a biopsy from his second allograft showing kappa-restricted crystalline light chain podocytopathy, which was identified in both his native and first allograft kidneys upon retrospective review. Recurrent light chain podocytopathy has not been previously reported but poses a diagnostic challenge as it can mimic focal segmental glomerulosclerosis, particularly in young patients in whom paraprotein-related kidney injury is usually not suspected.

AB - Kidney injury related to paraproteinemia is common and typically occurs after the fourth decade of life in association with an underlying plasma cell dyscrasia or other lymphoproliferative disease. Kidney transplantation in paraprotein-related kidney disease can be successful in conjunction with treatment of the underlying hematopoietic process; however, when hematologic response to therapy is not achieved, recurrent kidney injury is frequently seen. We describe a young male patient who presented at the age of 23 years with end-stage kidney disease thought to be secondary to focal segmental glomerulosclerosis; this patient ultimately received two kidney allografts. He experienced recurrent proteinuria in both kidneys, with a biopsy from his second allograft showing kappa-restricted crystalline light chain podocytopathy, which was identified in both his native and first allograft kidneys upon retrospective review. Recurrent light chain podocytopathy has not been previously reported but poses a diagnostic challenge as it can mimic focal segmental glomerulosclerosis, particularly in young patients in whom paraprotein-related kidney injury is usually not suspected.

KW - biopsy

KW - cancer/malignancy/neoplasia: hematogenous/leukemia/lymphoma

KW - clinical research/practice

KW - kidney (allograft) function/dysfunction

KW - kidney transplantation/nephrology

KW - pathology/histopathology

UR - http://www.scopus.com/inward/record.url?scp=85003845087&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85003845087&partnerID=8YFLogxK

U2 - 10.1111/ajt.14088

DO - 10.1111/ajt.14088

M3 - Article

C2 - 27775221

AN - SCOPUS:85003845087

VL - 17

SP - 824

EP - 829

JO - American Journal of Transplantation

JF - American Journal of Transplantation

SN - 1600-6135

IS - 3

ER -