Ligand-conjugated quantum dots for targeted drug delivery to nerve cells

Tothu (Tania) Vu, Ravikanth Maddipati, Todd A. Blute, Barrett J. Nehilla, Leora Nusblat, Tejal A. Desai

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Increased interest in nanoparticle quantum dots as fluorescent probes possessing extended photostability, multi-color capability, and surface-controllable properties has made apparent their promising potential for biological and therapeutic applications. As an approach towards surface-functionalized nanoparticle drug delivery, here we report the development of quantum dots (QDs) complexed with the small peptide hormone ßNGF. Surface modification and composition of ligand-conjugated QDs were confirmed using atomic force microscopy. Bioactivity and visual localization of ligand-QD complexes was assayed in live cells. Despite known structural and chemical stringency of ligand-receptor activation, we provide evidence to support activation of cell-surface trkA membrane receptor channels and downstream modulation of neurite sprouting. This QD-based capability bears significance for development of surface-conjugated nanoparticle drug delivery.

Original languageEnglish (US)
Title of host publication2005 3rd IEEE/EMBS Special Topic Conference on Microtechnology in Medicine and Biology
Pages152-153
Number of pages2
Volume2005
DOIs
StatePublished - 2005
Event2005 3rd IEEE/EMBS Special Topic Conference on Microtechnology in Medicine and Biology - Oahu, HI, United States
Duration: May 12 2005May 15 2005

Other

Other2005 3rd IEEE/EMBS Special Topic Conference on Microtechnology in Medicine and Biology
CountryUnited States
CityOahu, HI
Period5/12/055/15/05

Fingerprint

Semiconductor quantum dots
Neurons
Ligands
Nanoparticles
Drug delivery
Chemical activation
Bioactivity
Surface structure
Surface properties
Surface treatment
Atomic force microscopy
Modulation
Targeted drug delivery
Color
Membranes

Keywords

  • AFM
  • Drug delivery
  • Ligand
  • Nanobiotechnology
  • Nanostructures
  • Neuron
  • Quantum dots
  • Receptor
  • Stimulation

ASJC Scopus subject areas

  • Engineering(all)

Cite this

Vu, T. T., Maddipati, R., Blute, T. A., Nehilla, B. J., Nusblat, L., & Desai, T. A. (2005). Ligand-conjugated quantum dots for targeted drug delivery to nerve cells. In 2005 3rd IEEE/EMBS Special Topic Conference on Microtechnology in Medicine and Biology (Vol. 2005, pp. 152-153). [1548410] https://doi.org/10.1109/MMB.2005.1548410

Ligand-conjugated quantum dots for targeted drug delivery to nerve cells. / Vu, Tothu (Tania); Maddipati, Ravikanth; Blute, Todd A.; Nehilla, Barrett J.; Nusblat, Leora; Desai, Tejal A.

2005 3rd IEEE/EMBS Special Topic Conference on Microtechnology in Medicine and Biology. Vol. 2005 2005. p. 152-153 1548410.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Vu, TT, Maddipati, R, Blute, TA, Nehilla, BJ, Nusblat, L & Desai, TA 2005, Ligand-conjugated quantum dots for targeted drug delivery to nerve cells. in 2005 3rd IEEE/EMBS Special Topic Conference on Microtechnology in Medicine and Biology. vol. 2005, 1548410, pp. 152-153, 2005 3rd IEEE/EMBS Special Topic Conference on Microtechnology in Medicine and Biology, Oahu, HI, United States, 5/12/05. https://doi.org/10.1109/MMB.2005.1548410
Vu TT, Maddipati R, Blute TA, Nehilla BJ, Nusblat L, Desai TA. Ligand-conjugated quantum dots for targeted drug delivery to nerve cells. In 2005 3rd IEEE/EMBS Special Topic Conference on Microtechnology in Medicine and Biology. Vol. 2005. 2005. p. 152-153. 1548410 https://doi.org/10.1109/MMB.2005.1548410
Vu, Tothu (Tania) ; Maddipati, Ravikanth ; Blute, Todd A. ; Nehilla, Barrett J. ; Nusblat, Leora ; Desai, Tejal A. / Ligand-conjugated quantum dots for targeted drug delivery to nerve cells. 2005 3rd IEEE/EMBS Special Topic Conference on Microtechnology in Medicine and Biology. Vol. 2005 2005. pp. 152-153
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