Levels of the Candida metabolite D-arabinitol in sera of steroid-treated and untreated patients with sarcoidosis

Brian Wong, R. P. Baughman, K. L. Brauer

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

We measured the Candida metabolite D-arabinitol and its enantiomer L-arabinitol in 42 serum samples from 33 patients with sarcoidosis and compared the results with those from 27 healthy adults and 4 patients with candidiasis. The D- and L-arabinitol concentrations and the D- and L-arabinitol/creatinine ratios did not differ significantly in the sarcoidosis patients and the controls; the D-arabinitol concentrations and the D-arabinitol/creatinine ratios were much higher in the paitnets with candidiasis. Among the patients with sarcoidosis, the D- and L-arabinitol levels in the steroid recepients did not differ significantly from those in patients not receiving steroids. Higher D-arabinitol/creatinine ratios were associated with roentgenographic evidence of pulmonary fibrosis and low forced vital capacities, but not with disease activity as determined by the proportion of lymphocytes to total nucleated cells in bronchoalveolar lavage fluid or the CD4/CD8 ratio in bronchoalveolar lymphocytes. We conclude that neither sarcoidosis nor corticosteroid treatment is associated with high levels of D-arabinitol in serum.

Original languageEnglish (US)
Pages (from-to)1859-1862
Number of pages4
JournalJournal of Clinical Microbiology
Volume27
Issue number8
StatePublished - 1989
Externally publishedYes

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Sarcoidosis
Candida
Steroids
Serum
Creatinine
Candidiasis
arabitol
Lymphocytes
CD4-CD8 Ratio
Pulmonary Fibrosis
Vital Capacity
Bronchoalveolar Lavage Fluid
Adrenal Cortex Hormones

ASJC Scopus subject areas

  • Microbiology
  • Microbiology (medical)

Cite this

Levels of the Candida metabolite D-arabinitol in sera of steroid-treated and untreated patients with sarcoidosis. / Wong, Brian; Baughman, R. P.; Brauer, K. L.

In: Journal of Clinical Microbiology, Vol. 27, No. 8, 1989, p. 1859-1862.

Research output: Contribution to journalArticle

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abstract = "We measured the Candida metabolite D-arabinitol and its enantiomer L-arabinitol in 42 serum samples from 33 patients with sarcoidosis and compared the results with those from 27 healthy adults and 4 patients with candidiasis. The D- and L-arabinitol concentrations and the D- and L-arabinitol/creatinine ratios did not differ significantly in the sarcoidosis patients and the controls; the D-arabinitol concentrations and the D-arabinitol/creatinine ratios were much higher in the paitnets with candidiasis. Among the patients with sarcoidosis, the D- and L-arabinitol levels in the steroid recepients did not differ significantly from those in patients not receiving steroids. Higher D-arabinitol/creatinine ratios were associated with roentgenographic evidence of pulmonary fibrosis and low forced vital capacities, but not with disease activity as determined by the proportion of lymphocytes to total nucleated cells in bronchoalveolar lavage fluid or the CD4/CD8 ratio in bronchoalveolar lymphocytes. We conclude that neither sarcoidosis nor corticosteroid treatment is associated with high levels of D-arabinitol in serum.",
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