Lesions of the periaqueductal gray disrupt input to the rostral ventromedial medulla following microinjections of morphine into the medial or basolateral nuclei of the amygdala

Steve McGaraughty, Dawson A. Farr, Mary M. Heinricher

Research output: Contribution to journalArticle

34 Scopus citations

Abstract

Microinjections of morphine into the basolateral (BLa) and medial (MEa) nuclei of the amygdala differentially affect rostral ventromedial medulla (RVM) neuronal activity and nocifensive behaviors. PAG lesions attenuated or blocked the effects of both BLa and MEa morphine on RVM cell activity, and interfered with the behavioral antinociception produced by BLa infusions. These results demonstrate that the influences from both the BLa and MEa to the RVM are relayed via the PAG.

Original languageEnglish (US)
Pages (from-to)223-227
Number of pages5
JournalBrain research
Volume1009
Issue number1-2
DOIs
StatePublished - May 29 2004

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Keywords

  • Amygdala
  • Opioid
  • Pain modulation: anatomy and physiology
  • Periaqueductal gray
  • Rostral ventromedial medulla
  • Sensory systems

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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