Lesions of the periaqueductal gray disrupt input to the rostral ventromedial medulla following microinjections of morphine into the medial or basolateral nuclei of the amygdala

Steve McGaraughty; Dawson A. Farr; Mary M. Heinricher

doi:10.1016/j.brainres.2004.02.048

Lesions of the periaqueductal gray disrupt input to the rostral ventromedial medulla following microinjections of morphine into the medial or basolateral nuclei of the amygdala

Steve McGaraughty, Dawson A. Farr, Mary M. Heinricher

Research output: Contribution to journal › Article › peer-review

43 Scopus citations

Abstract

Microinjections of morphine into the basolateral (BLa) and medial (MEa) nuclei of the amygdala differentially affect rostral ventromedial medulla (RVM) neuronal activity and nocifensive behaviors. PAG lesions attenuated or blocked the effects of both BLa and MEa morphine on RVM cell activity, and interfered with the behavioral antinociception produced by BLa infusions. These results demonstrate that the influences from both the BLa and MEa to the RVM are relayed via the PAG.

Original language	English (US)
Pages (from-to)	223-227
Number of pages	5
Journal	Brain research
Volume	1009
Issue number	1-2
DOIs	https://doi.org/10.1016/j.brainres.2004.02.048
State	Published - May 29 2004

Keywords

Amygdala
Opioid
Pain modulation: anatomy and physiology
Periaqueductal gray
Rostral ventromedial medulla
Sensory systems

ASJC Scopus subject areas

General Neuroscience
Molecular Biology
Clinical Neurology
Developmental Biology

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10.1016/j.brainres.2004.02.048

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title = "Lesions of the periaqueductal gray disrupt input to the rostral ventromedial medulla following microinjections of morphine into the medial or basolateral nuclei of the amygdala",

abstract = "Microinjections of morphine into the basolateral (BLa) and medial (MEa) nuclei of the amygdala differentially affect rostral ventromedial medulla (RVM) neuronal activity and nocifensive behaviors. PAG lesions attenuated or blocked the effects of both BLa and MEa morphine on RVM cell activity, and interfered with the behavioral antinociception produced by BLa infusions. These results demonstrate that the influences from both the BLa and MEa to the RVM are relayed via the PAG.",

keywords = "Amygdala, Opioid, Pain modulation: anatomy and physiology, Periaqueductal gray, Rostral ventromedial medulla, Sensory systems",

author = "Steve McGaraughty and Farr, {Dawson A.} and Heinricher, {Mary M.}",

note = "Funding Information: This research was supported by grants from NIDA (DA05608) and the Medical Research Foundation of Oregon. SM was supported by an INVEST fellowship from NIDA.",

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AU - Farr, Dawson A.

AU - Heinricher, Mary M.

N1 - Funding Information: This research was supported by grants from NIDA (DA05608) and the Medical Research Foundation of Oregon. SM was supported by an INVEST fellowship from NIDA.

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AB - Microinjections of morphine into the basolateral (BLa) and medial (MEa) nuclei of the amygdala differentially affect rostral ventromedial medulla (RVM) neuronal activity and nocifensive behaviors. PAG lesions attenuated or blocked the effects of both BLa and MEa morphine on RVM cell activity, and interfered with the behavioral antinociception produced by BLa infusions. These results demonstrate that the influences from both the BLa and MEa to the RVM are relayed via the PAG.

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Lesions of the periaqueductal gray disrupt input to the rostral ventromedial medulla following microinjections of morphine into the medial or basolateral nuclei of the amygdala

Abstract

Keywords

ASJC Scopus subject areas

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