Lesions of the Edinger-Westphal nucleus alter food and water consumption

Adam Z. Weitemier, Andrey Ryabinin

Research output: Contribution to journalArticle

41 Citations (Scopus)

Abstract

The Edinger-Westphal nucleus (EW) produces several neuropeptides, including urocortin 1 and cocaine-amphetamine-regulated transcript, which regulate feeding, energy balance, and anxiety. Additionally, the EW projects to feeding and anxiety-regulatory brain areas. The authors tested the effect of lesions of the EW on the consumption of food, water and flavored solutions, metabolic indices, and exploratory behavior on the elevated plus maze in male C57BL/6J mice. EW lesion significantly reduced basal and deprivation-induced food and fluid consumption compared with sham and placement controls, but it did not alter behavior on the elevated plus maze. EW lesion had no effect on indices of basal metabolic activity, including plasma glucose level and body temperature. These effects suggest that the peptidergic neurons of the EW regulate food consumption.

Original languageEnglish (US)
Pages (from-to)1235-1243
Number of pages9
JournalBehavioral Neuroscience
Volume119
Issue number5
DOIs
StatePublished - Oct 2005
Externally publishedYes

Fingerprint

Drinking
Food
Anxiety
Urocortins
Food Deprivation
Exploratory Behavior
Amphetamine
Neuropeptides
Body Temperature
Inbred C57BL Mouse
Cocaine
Edinger-Westphal Nucleus
Neurons
Glucose
Brain

Keywords

  • Corticotropin
  • Elevated plus maze
  • Feeding
  • Gastrointestinal
  • Mouse

ASJC Scopus subject areas

  • Behavioral Neuroscience
  • Clinical Psychology

Cite this

Lesions of the Edinger-Westphal nucleus alter food and water consumption. / Weitemier, Adam Z.; Ryabinin, Andrey.

In: Behavioral Neuroscience, Vol. 119, No. 5, 10.2005, p. 1235-1243.

Research output: Contribution to journalArticle

@article{edb89f725a22419ea9b51c127136416f,
title = "Lesions of the Edinger-Westphal nucleus alter food and water consumption",
abstract = "The Edinger-Westphal nucleus (EW) produces several neuropeptides, including urocortin 1 and cocaine-amphetamine-regulated transcript, which regulate feeding, energy balance, and anxiety. Additionally, the EW projects to feeding and anxiety-regulatory brain areas. The authors tested the effect of lesions of the EW on the consumption of food, water and flavored solutions, metabolic indices, and exploratory behavior on the elevated plus maze in male C57BL/6J mice. EW lesion significantly reduced basal and deprivation-induced food and fluid consumption compared with sham and placement controls, but it did not alter behavior on the elevated plus maze. EW lesion had no effect on indices of basal metabolic activity, including plasma glucose level and body temperature. These effects suggest that the peptidergic neurons of the EW regulate food consumption.",
keywords = "Corticotropin, Elevated plus maze, Feeding, Gastrointestinal, Mouse",
author = "Weitemier, {Adam Z.} and Andrey Ryabinin",
year = "2005",
month = "10",
doi = "10.1037/0735-7044.119.5.1235",
language = "English (US)",
volume = "119",
pages = "1235--1243",
journal = "Behavioral Neuroscience",
issn = "0735-7044",
publisher = "American Psychological Association Inc.",
number = "5",

}

TY - JOUR

T1 - Lesions of the Edinger-Westphal nucleus alter food and water consumption

AU - Weitemier, Adam Z.

AU - Ryabinin, Andrey

PY - 2005/10

Y1 - 2005/10

N2 - The Edinger-Westphal nucleus (EW) produces several neuropeptides, including urocortin 1 and cocaine-amphetamine-regulated transcript, which regulate feeding, energy balance, and anxiety. Additionally, the EW projects to feeding and anxiety-regulatory brain areas. The authors tested the effect of lesions of the EW on the consumption of food, water and flavored solutions, metabolic indices, and exploratory behavior on the elevated plus maze in male C57BL/6J mice. EW lesion significantly reduced basal and deprivation-induced food and fluid consumption compared with sham and placement controls, but it did not alter behavior on the elevated plus maze. EW lesion had no effect on indices of basal metabolic activity, including plasma glucose level and body temperature. These effects suggest that the peptidergic neurons of the EW regulate food consumption.

AB - The Edinger-Westphal nucleus (EW) produces several neuropeptides, including urocortin 1 and cocaine-amphetamine-regulated transcript, which regulate feeding, energy balance, and anxiety. Additionally, the EW projects to feeding and anxiety-regulatory brain areas. The authors tested the effect of lesions of the EW on the consumption of food, water and flavored solutions, metabolic indices, and exploratory behavior on the elevated plus maze in male C57BL/6J mice. EW lesion significantly reduced basal and deprivation-induced food and fluid consumption compared with sham and placement controls, but it did not alter behavior on the elevated plus maze. EW lesion had no effect on indices of basal metabolic activity, including plasma glucose level and body temperature. These effects suggest that the peptidergic neurons of the EW regulate food consumption.

KW - Corticotropin

KW - Elevated plus maze

KW - Feeding

KW - Gastrointestinal

KW - Mouse

UR - http://www.scopus.com/inward/record.url?scp=27744532724&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=27744532724&partnerID=8YFLogxK

U2 - 10.1037/0735-7044.119.5.1235

DO - 10.1037/0735-7044.119.5.1235

M3 - Article

C2 - 16300431

AN - SCOPUS:27744532724

VL - 119

SP - 1235

EP - 1243

JO - Behavioral Neuroscience

JF - Behavioral Neuroscience

SN - 0735-7044

IS - 5

ER -