Leptin and insulin in young adulthood are associated with weight in infancy

Umberto Simeoni, Clive Osmond, Ricardo Garay, Christophe Buffat, Farid Boubred, Christophe Chagnaud, Elisabeth Jouve, Christine Audebert, Jean Michel Antoine, Kent Thornburg

    Research output: Contribution to journalArticle

    1 Scopus citations

    Abstract

    Low weight in early infancy is a known risk factor for cardio-metabolic syndrome in adult life. However, little is known either about developmental programming in subjects of normal birthweight or about events between the ages which separate early programming and the occurrence of disease at late adulthood. We tested the hypothesis that circulating concentrations of leptin, adiponectin and insulin in young, healthy adults, born with a birth size within the normal range, are influenced by early life growth patterns. In an observational study of 188 healthy volunteers aged 18–25 years (97 males, 91 females) we investigated the association of metabolic function with their birth size, their growth during childhood and their body composition. High plasma leptin in early adulthood, a risk factor for cardio-metabolic syndrome, was associated with low weight at age 2 years (correlation coefficient controlled for adult weight = −0.21, P < 0.01). It was also positively associated with pre-prandial insulin and with HOMA (Homeostasis Model Assessment) insulin resistance. Leptin, leptin-adiponectin ratio and insulin correlated with lean mass, fat mass and percent fat (P < 0.0001). In conclusion, high leptin in early adulthood was associated with both low weight at age 2 years and insulin resistance. We speculate that high leptin is developmentally programmed and can contribute to the association between low weight in early infancy and increased cardio-metabolic risk in adulthood in healthy subjects.

    Original languageEnglish (US)
    Pages (from-to)249-259
    Number of pages11
    JournalJournal of Endocrinology
    Volume244
    Issue number2
    DOIs
    StatePublished - Jan 1 2020

    Keywords

    • Adiponectin
    • Birth weight
    • Coronary artery disease diabetes
    • Leptin
    • Metabolic syndrome
    • Percentage fat

    ASJC Scopus subject areas

    • Endocrinology, Diabetes and Metabolism
    • Endocrinology

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  • Cite this

    Simeoni, U., Osmond, C., Garay, R., Buffat, C., Boubred, F., Chagnaud, C., Jouve, E., Audebert, C., Antoine, J. M., & Thornburg, K. (2020). Leptin and insulin in young adulthood are associated with weight in infancy. Journal of Endocrinology, 244(2), 249-259. https://doi.org/10.1530/JOE-18-0538