Laser catheter ablation of simulated ventricular tachycardia

G. M. Vincent, J. Fox, B. A. Benedick, John Hunter, J. A. Dixon

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Catheter-directed laser injury of the left ventricular endocardium for ablation of ventricular tachycardia was studied in a canine model of simulated ventricular tachycardia. Bipolar plunge electrodes were placed at thoracotomy into the left ventricular endocardium in nine anesthetized dogs. Ventricular tachycardia was simulated by pacing at 200 beats per minute. After four days of recovery, catheter-directed neodymium:yttrium-aluminum-garnet laser injury was produced at the site of earliest recorded electrical activation during pacing tachycardia as detected by endocardial catheter mapping. Immediately after laser injury and again five days after injury, pacing tachycardia was attempted. Failure to pace after laser injury was defined as successful arrhythmia ablation. In 3/9 (33%) experiments, the laser-injured tissue surrounded the tachycardia source (pacing wires) and pacing-simulated ventricular tachycardia was prevented. When the laser injury did not involve the tachycardia source, 6/9 animals, due to limitations of the mapping system, pacing was not prevented. One animal developed sustained ventricular tachycardia during laser injury, with conversion to sinus rhythm by lidocaine. One animal, without recognized ventricular arrhythmia, died five days after laser injury. No unusual findings were noted at autopsy. These preliminary data suggest that catheter-directed laser-induced injury can ablate arrhythmia sources. Further studies are indicated in a more physiologic model and the safety and risks of the procedure need further evaluation.

Original languageEnglish (US)
Pages (from-to)421-425
Number of pages5
JournalLasers in Surgery and Medicine
Volume7
Issue number5
StatePublished - 1987
Externally publishedYes

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Catheter Ablation
Laser Therapy
Ventricular Tachycardia
Lasers
Wounds and Injuries
Tachycardia
Catheters
Cardiac Arrhythmias
Endocardium
Neodymium
Solid-State Lasers
Thoracotomy
Lidocaine
Canidae
Autopsy
Electrodes
Dogs
Safety

ASJC Scopus subject areas

  • Surgery

Cite this

Vincent, G. M., Fox, J., Benedick, B. A., Hunter, J., & Dixon, J. A. (1987). Laser catheter ablation of simulated ventricular tachycardia. Lasers in Surgery and Medicine, 7(5), 421-425.

Laser catheter ablation of simulated ventricular tachycardia. / Vincent, G. M.; Fox, J.; Benedick, B. A.; Hunter, John; Dixon, J. A.

In: Lasers in Surgery and Medicine, Vol. 7, No. 5, 1987, p. 421-425.

Research output: Contribution to journalArticle

Vincent, GM, Fox, J, Benedick, BA, Hunter, J & Dixon, JA 1987, 'Laser catheter ablation of simulated ventricular tachycardia', Lasers in Surgery and Medicine, vol. 7, no. 5, pp. 421-425.
Vincent, G. M. ; Fox, J. ; Benedick, B. A. ; Hunter, John ; Dixon, J. A. / Laser catheter ablation of simulated ventricular tachycardia. In: Lasers in Surgery and Medicine. 1987 ; Vol. 7, No. 5. pp. 421-425.
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